Evidence map›Paper›PMID 27993858›Full record

ArticleAntimicrobial agents and chemotherapy2017

Repurposing Toremifene for Treatment of Oral Bacterial Infections.

Evelien Gerits, Valerie Defraine, Katleen Vandamme, Kaat De Cremer, Katrijn De Brucker, Karin Thevissen, Bruno P A Cammue, Serge Beullens, Maarten Fauvart, Natalie Verstraeten and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Old drugs, new weapons: current trends in repurposing therapies against antimicrobial resistance.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2026
    Review
  4. Stilbenes from Vine Extracts: Therapeutic Potential and Mechanisms.International journal of molecular sciences · 2025
    Review
  5. Review
  6. Article
  7. Deciphering meropenem persistence inAntimicrobial agents and chemotherapy · 2025
    Article
  8. Article
  9. Drug repurposing of Nifuratel against methicillin-resistantFrontiers in cellular and infection microbiology · 2025
    Article
  10. Review
  11. Review
  12. Review
  13. Comparison of Antimicrobial Activity againstInternational journal of biomaterials · 2023
    Article
  14. Article
  15. Study on the inhibitory effect of selective estrogen receptor modulators onHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2022
    Article
  16. Review
  17. Novel antimicrobial agents targeting theFrontiers in cellular and infection microbiology · 2022
    Review
  18. Small Molecule Compounds, A Novel Strategy againstPathogens (Basel, Switzerland) · 2021
    Review
  19. RSC medicinal chemistry · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Evelien GeritsKU Leuven, Centre of Microbial and Plant Genetics, Department of Microbial and Molecular Systems, Leuven, Belgium.
Valerie DefraineKU Leuven, Centre of Microbial and Plant Genetics, Department of Microbial and Molecular Systems, Leuven, Belgium.
Katleen VandammeUZ Leuven, Restorative Dentistry-KU Leuven, BIOMAT, Department of Oral Health Sciences, Leuven, Belgium.
Kaat De CremerKU Leuven, Centre of Microbial and Plant Genetics, Department of Microbial and Molecular Systems, Leuven, Belgium.
Katrijn De BruckerKU Leuven, Centre of Microbial and Plant Genetics, Department of Microbial and Molecular Systems, Leuven, Belgium.
Karin ThevissenKU Leuven, Centre of Microbial and Plant Genetics, Department of Microbial and Molecular Systems, Leuven, Belgium.
Bruno P A CammueKU Leuven, Centre of Microbial and Plant Genetics, Department of Microbial and Molecular Systems, Leuven, Belgium.
Serge BeullensKU Leuven, Centre of Microbial and Plant Genetics, Department of Microbial and Molecular Systems, Leuven, Belgium.
Maarten FauvartKU Leuven, Centre of Microbial and Plant Genetics, Department of Microbial and Molecular Systems, Leuven, Belgium.
Natalie VerstraetenKU Leuven, Centre of Microbial and Plant Genetics, Department of Microbial and Molecular Systems, Leuven, Belgium.
Jan MichielsKU Leuven, Centre of Microbial and Plant Genetics, Department of Microbial and Molecular Systems, Leuven, Belgium Jan.Michiels@kuleuven.be.
KU Leuven · BEVIB-UGent Center for Plant Systems Biology · BEUniversitair Ziekenhuis Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The spread of antibiotic resistance and the challenges associated with antiseptics such as chlorhexidine have necessitated a search for new antibacterial agents against oral bacterial pathogens. As a result of failing traditional approaches, drug repurposing has emerged as a novel paradigm to find new antibacterial agents. In this study, we examined the effects of the FDA-approved anticancer agent toremifene against the oral bacteria

Indexed as

Anti-Bacterial AgentsAntineoplastic Agents, HormonalBiofilmsCell MembraneCell Membrane PermeabilityDental PlaqueDrug RepositioningDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsPeriodontitisPorphyromonas gingivalisStreptococcus mutansTitaniumToremifeneAnti-Bacterial AgentsAntineoplastic Agents, HormonalTitaniumToremifenebiofilmsoral infectionsPorphyromonas gingivalisStreptococcus mutanstoremifene

Identifiers

PMID27993858
PMCPMC5328575
OpenAlexW2562708748

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.