Evidence map›Paper›PMID 27993852›Full record

ArticleAntimicrobial agents and chemotherapy2017

Increased Costs Associated with Bloodstream Infections Caused by Multidrug-Resistant Gram-Negative Bacteria Are Due Primarily to Patients with Hospital-Acquired Infections.

Joshua T Thaden, Yanhong Li, Felicia Ruffin, Stacey A Maskarinec, Jonathan M Hill-Rorie, Lisa C Wanda, Shelby D Reed, Vance G Fowler

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 6 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 6 syntheses or guidelines pooled it, 130 citations in OpenAlex.

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  16. Time-Sensitive Antibiotic Adjustments in Gram-Negative Bacteremia: A Survival Perspective.Medical science monitor : international medical journal of experimental and clinical research · 2025
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Joshua T ThadenDivision of Infectious Diseases, Duke University, Durham, North Carolina, USA.
Yanhong LiDuke Clinical Research Institute, Duke University, Durham, North Carolina, USA.
Felicia RuffinDivision of Infectious Diseases, Duke University, Durham, North Carolina, USA.
Stacey A MaskarinecDivision of Infectious Diseases, Duke University, Durham, North Carolina, USA.
Jonathan M Hill-RorieDivision of Infectious Diseases, Duke University, Durham, North Carolina, USA.
Lisa C WandaDivision of Infectious Diseases, Duke University, Durham, North Carolina, USA.
Shelby D ReedDuke Clinical Research Institute, Duke University, Durham, North Carolina, USA.
Vance G FowlerDivision of Infectious Diseases, Duke University, Durham, North Carolina, USA Vance.Fowler@duke.edu.
Duke University · US

Funding

Increasing the Quality and Efficiency of Clinical Trials (R18)R18FD005292 · FDA · DUKE UNIVERSITY · PI LI, JENNIFER S · 2014 to 2019
$26.8M
Tri-Institutional Molecular Mycology and Pathogenesis Training ProgramT32AI052080 · NIAID · DUKE UNIVERSITY · PI ANDREW ALSPAUGH, JOSEPH HEITMAN · 2003 to 2026
$8.7M
Mentoring Patient Oriented Research in Antibiotic-Resistant BacteriaK24AI093969 · NIAID · DUKE UNIVERSITY · PI FOWLER, VANCE G. · 2011 to 2020
$1.6M
FDA HHS R18 FD005292NIAID NIH HHS K24 AI093969NIAID NIH HHS T32 AI052080
6 · The paper itself

Abstract

The clinical and economic impacts of bloodstream infections (BSI) due to multidrug-resistant (MDR) Gram-negative bacteria are incompletely understood. From 2009 to 2015, all adult inpatients with Gram-negative BSI at our institution were prospectively enrolled. MDR status was defined as resistance to ≥3 antibiotic classes. Clinical outcomes and inpatient costs associated with the MDR phenotype were identified. Among 891 unique patients with Gram-negative BSI, 292 (33%) were infected with MDR bacteria. In an adjusted analysis, only history of Gram-negative infection was associated with MDR BSI versus non-MDR BSI (odds ratio, 1.60; 95% confidence interval [CI], 1.19 to 2.16;

Indexed as

Drug Resistance, Multiple, BacterialAgedAnti-Bacterial AgentsBacteremiaCross InfectionFemaleGram-Negative Bacterial InfectionsHealth Care CostsHospital MortalityHumansLength of StayMaleMiddle AgedNorth CarolinaProspective StudiesSurvival AnalysisAnti-Bacterial Agentsbloodstream infectioncostGram negative

Identifiers

PMID27993852
PMCPMC5328522
OpenAlexW2565309317

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.