Evidence map›Paper›PMID 27993846›Full record

ArticleAntimicrobial agents and chemotherapy2017

Nonnucleoside Reverse Transcriptase Inhibitors Reduce HIV-1 Production from Latently Infected Resting CD4

Jennifer M Zerbato, Gilda Tachedjian, Nicolas Sluis-Cremer

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. CARD8 Inflammasome Activation by HIV-1 Protease.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jennifer M ZerbatoDivision of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Gilda TachedjianCentre for Biomedical Research, Burnet Institute, Melbourne, Victoria, Australia.
Nicolas Sluis-CremerDivision of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA nps2@pitt.edu.

Funding

NNRTI induced conformational changes in HIV-1 RT - Equipment SupplementR01GM068406 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SLUIS-CREMER, NICOLAS PAUL · 2003 to 2017
$3.7M
The "Kick" Revisited in the "Kick and Kill" StrategyR21AI119117 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SLUIS-CREMER, NICOLAS PAUL · 2016 to 2017
$410k
NIAID NIH HHS R21 AI119117NIGMS NIH HHS R01 GM068406
6 · The paper itself

Abstract

Therapeutic strategies that target the latent HIV-1 reservoir in resting CD4

Indexed as

Adjuvants, ImmunologicAlkynesAntibodies, MonoclonalAntibodies, ViralAnti-HIV AgentsBenzoxazinesBryostatinsCD28 AntigensCD3 ComplexCD4-Positive T-LymphocytesCyclopropanesGene ExpressionHIV-1HumansInterleukin-2Primary Cell CultureAdjuvants, ImmunologicAlkynesAntibodies, MonoclonalAntibodies, ViralAnti-HIV AgentsBenzoxazinesbryostatin 1BryostatinsCD28 AntigensCD3 ComplexCyclopropanesefavirenzInterleukin-2RilpivirineHIV-1latencyNNRTIspersistencereservoir

Identifiers

PMID27993846
PMCPMC5328526

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.