Trial reportJournal of the American Heart Association2016
Relationship Between Endothelial Wall Shear Stress and High-Risk Atherosclerotic Plaque Characteristics for Identification of Coronary Lesions That Cause Ischemia: A Direct Comparison With Fractional Flow Reserve.
Trial report in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Brachial artery wall shear stress as measured by ultrasound vector flow imaging for evaluating arteriovenous fistula stenosis in patients on hemodialysis.Quantitative imaging in medicine and surgery · 2026Article
- Association of atherosclerotic cardiovascular disease risk stratification with carotid wall shear stress as measured by vector flow mapping: a study of a Chinese population.Quantitative imaging in medicine and surgery · 2026Article
- Water Hammer Phenomenon in Coronary Arteries: Scientific Basis for Diagnostic and Predictive Modeling with Acoustic Action Mapping.Diagnostics (Basel, Switzerland) · 2025Review
- [Coronary CT Angiography-Based Mechanomics Predicts Atherosclerotic Plaque Formation in Regions Proximal to Myocardial Bridging].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- Evaluation of Carotid Stenosis in a High-Stroke-Risk Population by Hemodynamic Dual-Parameters Based on Ultrasound Vector Flow Imaging.Brain and behavior · 2024Article
- Patient-Specific Numerical Simulations of Coronary Artery Hemodynamics and Biomechanics: A Pathway to Clinical Use.Cardiovascular engineering and technology · 2024Review
- Advances in the Computational Assessment of Disturbed Coronary Flow and Wall Shear Stress: A Contemporary Review.Journal of the American Heart Association · 2024Review
- Predicting coronary artery occlusion risk from noninvasive images by combining CFD-FSI, cGAN and CNN.Scientific reports · 2024Article
- Charting the Unseen: How Non-Invasive Imaging Could Redefine Cardiovascular Prevention.Journal of cardiovascular development and disease · 2024Review
- Integrating Computational and Biological Hemodynamic Approaches to Improve Modeling of Atherosclerotic Arteries.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- The hemodynamic and geometric characteristics of carotid artery atherosclerotic plaque formation.Quantitative imaging in medicine and surgery · 2024Article
- Evaluating the association between vascular remodeling and plaque calcification patterns of the carotid artery and its effects on ischemic symptoms using CT angiography.Cardiovascular diagnosis and therapy · 2024Article
- Cardiac Computed Tomography Angiography in CAD Risk Stratification and Revascularization Planning.Diagnostics (Basel, Switzerland) · 2023Review
- Glagov revisited: coronary artery disease phenotype on non-invasive imaging provides rationale for implementing preventive pharmacotherapy-a case report.European heart journal. Case reports · 2023Article
- Development of a Model for Plaque Induction in Rat Carotid Arteries.Asian journal of neurosurgery · 2023Article
- Computational Study of Hemodynamic Field of an Occluded Artery Model with Anastomosis.Bioengineering (Basel, Switzerland) · 2023Article
- A review on non-Newtonian fluid models for multi-layered blood rheology in constricted arteries.Archive of applied mechanics = Ingenieur-Archiv · 2023Review
- The Need to Shift from Morphological to Structural Assessment for Carotid Plaque Vulnerability.Biomedicines · 2022Article
- Detailed behaviour of endothelial wall shear stress across coronary lesions from non-invasive imaging with coronary computed tomography angiography.European heart journal. Cardiovascular Imaging · 2022Article
- The Effects of the Mechanical Properties of Vascular Grafts and an Anisotropic Hyperelastic Aortic Model on Local Hemodynamics during Modified Blalock-Taussig Shunt Operation, Assessed Using FSI Simulation.Materials (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWall shear stress (WSS) is an established predictor of coronary atherosclerosis progression. Prior studies have reported that high WSS has been associated with high-risk atherosclerotic plaque characteristics (APCs). WSS and APCs are quantifiable by coronary computed tomography angiography, but the relationship of coronary lesion ischemia-evaluated by fractional flow reserve-to WSS and APCs has not been examined. METHODS AND
resultsWSS measures were obtained from 100 evaluable patients who underwent coronary computed tomography angiography and invasive coronary angiography with fractional flow reserve. Patients were categorized according to tertiles of mean WSS values defined as low, intermediate, and high. Coronary ischemia was defined as fractional flow reserve ≤0.80. Stenosis severity was determined by minimal luminal diameter. APCs were defined as positive remodeling, low attenuation plaque, and spotty calcification. The likelihood of having positive remodeling and low-attenuation plaque was greater in the high WSS group compared with the low WSS group after adjusting for minimal luminal diameter (odds ratio for positive remodeling: 2.54, 95% CI 1.12-5.77; odds ratio for low-attenuation plaque: 2.68, 95% CI 1.02-7.06; both P<0.05). No significant relationship was observed between WSS and fractional flow reserve when adjusting for either minimal luminal diameter or APCs. WSS displayed no incremental benefit above stenosis severity and APCs for detecting lesions that caused ischemia (area under the curve for stenosis and APCs: 0.87, 95% CI 0.81-0.93; area under the curve for stenosis, APCs, and WSS: 0.88, 95% CI 0.82-0.93; P=0.30 for difference).
conclusionsHigh WSS is associated with APCs independent of stenosis severity. WSS provided no added value beyond stenosis severity and APCs for detecting lesions with significant ischemia.
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