Evidence map›Paper›PMID 27993830›Full record

ArticleJournal of the American Heart Association2016

Secondhand Smoke Exposure and Subclinical Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis.

Miranda R Jones, Hoda S Magid, Mahmoud Al-Rifai, John W McEvoy, Joel D Kaufman, Karen D Hinckley Stukovsky, Moyses Szklo, Joseph Polak, Gregory L Burke, Wendy S Post and 2 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Subnational exposure to secondhand smoke in Iran from 1990 to 2013: a systematic review.Environmental science and pollution research international · 2021
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Subclinical cardiovascular disease and utility of coronary artery calcium score.International journal of cardiology. Heart & vasculature · 2021
    Review
  12. Review
  13. Second-Hand Smoke and Its Synergistic Effect with a Body-Mass Index of >24.9 kg/mInternational journal of environmental research and public health · 2021
    Article
  14. Article
  15. Smoking and the Pathophysiology of Peripheral Artery Disease.Frontiers in cardiovascular medicine · 2021
    Review
  16. Article
  17. Second-Hand Smoke Exposure Among Coronary Heart Disease Patients.Journal of multidisciplinary healthcare · 2020
    Article
  18. Article
  19. Review
  20. Environmental Tobacco Smoke and Cardiovascular Disease.International journal of environmental research and public health · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Miranda R JonesDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD mjone132@jhu.edu.
Hoda S MagidDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Mahmoud Al-RifaiDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
John W McEvoyDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Joel D KaufmanDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA.
Karen D Hinckley StukovskyDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA.
Moyses SzkloDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Joseph PolakDepartment of Radiology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA.
Gregory L BurkeDivision of Public Health Sciences, Wake Forest School of Medicine, Winston- Salem, NC.
Wendy S PostDivision of Cardiology, Johns Hopkins University, Baltimore, MD.
Michael J BlahaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Ana Navas-AcienDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Johns Hopkins University · USUniversity of Washington · USTufts Medical Center · USWake Forest University · US

Funding

Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Research Training and Education Core (Core D) P50HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BHATNAGAR, ARUNI, ROBERTSON, ROSE MARIE · 2013 to 2017
$20.1M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
INSTITUTIONAL RESEARCH CANCER EPIDEMIOLOGY FELLOWSHIPT32CA009314 · NCI · JOHNS HOPKINS UNIVERSITY · PI Corinne E. Joshu, Meghan Bridgid Moran · 1985 to 2026
$11.2M
NCATS NIH HHS UL1 TR001420NCI NIH HHS T32 CA009314NHLBI NIH HHS P50 HL120163NHLBI NIH HHS R01 HL077612
6 · The paper itself

Abstract

backgroundFew studies have evaluated the association between secondhand smoke (SHS) and subclinical cardiovascular disease among ethnically diverse populations. This study assesses the impact of SHS on inflammation and atherosclerosis (carotid intima-media thickness, coronary artery calcification, and peripheral arterial disease). METHODS AND

resultsWe examined 5032 nonsmoking adults aged 45 to 84 years without prior cardiovascular disease participating in the Multi-Ethnic Study of Atherosclerosis (MESA) from 2000 to 2002. SHS exposure was determined by self-report, and urinary cotinine was measured in a representative subset (n=2893). The multi-adjusted geometric mean ratios (95% CIs) for high-sensitivity C-reactive protein and interleukin-6 comparing 407 participants with SHS ≥12 h/wk versus 3035 unexposed participants were 1.13 (1.02-1.26) and 1.04 (0.98-1.11), respectively. The multi-adjusted geometric mean ratio for carotid intima-media thickness was 1.02 (0.97-1.07). Fibrinogen and coronary artery calcification were not associated with SHS. The prevalence of peripheral arterial disease (ankle-brachial index ≤0.9 or ≥1.4) was associated with detectable urinary cotinine (odds ratio, 2.10; 95% CI, 1.09-4.04) but not with self-reported SHS. Urinary cotinine was not associated with inflammation or carotid intima-media thickness.

conclusionsDespite limited exposure assessment, this study supports the association of SHS exposure with inflammation and peripheral arterial disease.

Indexed as

AdultAgedAged, 80 and overAnalysis of VarianceAnkle Brachial IndexAsianAtherosclerosisBiomarkersBlack or African AmericanCarotid Intima-Media ThicknessCoronary Artery DiseaseHispanic or LatinoHumansMiddle AgedPeripheral Arterial DiseaseProspective StudiesBiomarkersTobacco Smoke Pollutionankle‐brachial indexatherosclerosiscarotid intima‐media thicknesscoronary artery calciuminflammationperipheral artery diseasesecondhand smokesmoking

Identifiers

PMID27993830
PMCPMC5210438
OpenAlexW2566460704

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.