ArticleCerebral cortex (New York, N.Y. : 1991)2017
Parsing the Role of the Hippocampus in Approach-Avoidance Conflict.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- A simple alternative to nondeceptive placebos for reducing emotional distress: encouragement.Social cognitive and affective neuroscience · 2025Trial
- Amygdala Lesions Reduce Anxiety-like Behavior in a Human Benzodiazepine-Sensitive Approach-Avoidance Conflict Test.Biological psychiatry · 2017Trial
- Dissecting the Function of Hippocampal Oscillations in a Human Anxiety Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Trial
- The neurocognitive mechanism underlying math avoidance among math anxious people.NPJ science of learning · 2025Article
- Hippocampal damage disrupts the latent decision-making processes underlying approach-avoidance conflict processing in humans.PLoS biology · 2025Article
- Motivated with joy or anxiety: Does approach-avoidance goal framing elicit differential reward-network activation in the brain?Cognitive, affective & behavioral neuroscience · 2024Article
- Elucidating medial temporal and frontal lobe contributions to approach-avoidance conflict decision-making using functional MRI and the hierarchical drift diffusion model.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Computational perspectives on human fear and anxiety.Neuroscience and biobehavioral reviews · 2023Review
- The anxiety-specific hippocampus-prefrontal cortex pathways links to procrastination through self-control.Human brain mapping · 2022Article
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- Perirhinal Cortex is Involved in the Resolution of Learned Approach-Avoidance Conflict Associated with Discrete Objects.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Conflict between Threat Sensitivity and Sensation Seeking in the Adolescent Brain: Role of the Hippocampus, and Neurobehavioural Plasticity Induced by Pleasurable Early Enriched Experience.Brain sciences · 2021Article
- Hippocampal Representation of Threat Features and Behavior in a Human Approach-Avoidance Conflict Anxiety Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Individual Differences in Hippocampal Volume as a Function of BMI and Reward Sensitivity.Frontiers in behavioral neuroscience · 2020Article
- Minimizing threat via heuristic and optimal policies recruits hippocampus and medial prefrontal cortex.Nature human behaviour · 2019Article
- Dopaminergic Mechanisms Underlying Normal Variation in Trait Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
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- Striatal reactivity during emotion and reward relates to approach-avoidance conflict behaviour and is altered in adults with anxiety or depression.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The hippocampus plays a central role in the approach-avoidance conflict that is central to the genesis of anxiety. However, its exact functional contribution has yet to be identified. We designed a novel gambling task that generated approach-avoidance conflict while controlling for spatial processing. We fit subjects' behavior using a model that quantified the subjective values of choice options, and recorded neural signals using functional magnetic resonance imaging (fMRI). Distinct functional signals were observed in anterior hippocampus, with inferior hippocampus selectively recruited when subjects rejected a gamble, to a degree that covaried with individual differences in anxiety. The superior anterior hippocampus, in contrast, uniquely demonstrated value signals that were potentiated in the context of approach-avoidance conflict. These results implicate the anterior hippocampus in behavioral avoidance and choice monitoring, in a manner relevant to understanding its role in anxiety. Our findings highlight interactions between subregions of the hippocampus as an important focus for future study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.