Evidence map›Paper›PMID 27993709›Full record

ArticleNeuroscience letters2017

Divergence and inheritance of neocortical heterotopia in inbred and genetically-engineered mice.

Alyssa R Toia, Joshua A Cuoco, Anthony W Esposito, Jawad Ahsan, Alok Joshi, Bruce J Herron, German Torres, Valerie J Bolivar, Raddy L Ramos

Open access · greenAbstract read
In one paragraph

Article in Neuroscience letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Alyssa R ToiaDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, United States.
Joshua A CuocoDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, United States.
Anthony W EspositoDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, United States.
Jawad AhsanDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, United States.
Alok JoshiDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, United States.
Bruce J HerronWadsworth Center, New York State Department of Health, Albany, NY, 12208, United States; Department of Biomedical Sciences, School of Public Health, State University of New York at Albany, Albany, NY, 12201, United States.
German TorresDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, United States.
Valerie J BolivarWadsworth Center, New York State Department of Health, Albany, NY, 12208, United States; Department of Biomedical Sciences, School of Public Health, State University of New York at Albany, Albany, NY, 12201, United States.
Raddy L RamosDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, United States. Electronic address: rramos02@nyit.edu.
New York Institute of Technology · USNew York State Department of Health · USWadsworth Center · US

Funding

Role of Draxin in Forebrain Connectivity and Complex BehaviorsR21MH103680 · NIMH · WADSWORTH CENTER · PI BOLIVAR, VALERIE J · 2014 to 2015
$396k
NIMH NIH HHS R21 MH103680
6 · The paper itself

Abstract

Cortical function emerges from the intrinsic properties of neocortical neurons and their synaptic connections within and across lamina. Neurodevelopmental disorders affecting migration and lamination of the neocortex result in cognitive delay/disability and epilepsy. Molecular layer heterotopia (MLH), a dysplasia characterized by over-migration of neurons into layer I, are associated with cognitive deficits and neuronal hyperexcitability in humans and mice. The breadth of different inbred mouse strains that exhibit MLH and inheritance patterns of heterotopia remain unknown. A neuroanatomical survey of numerous different inbred mouse strains, 2 first filial generation (F1) hybrids, and one consomic strain (C57BL/6J-Chr 1

Indexed as

AnimalsHomozygoteMalformations of Cortical Development, Group IIMice, Inbred C57BLMice, Inbred StrainsMice, TransgenicNeocortexPenetranceSpecies SpecificityC57BL/6HeterotopiaMalformationNeocortex

Identifiers

PMID27993709
PMCPMC5239770
OpenAlexW2564134044

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.