Observational studyAmerican journal of ophthalmology2017
Insights Into Epiretinal Membranes: Presence of Ectopic Inner Foveal Layers and a New Optical Coherence Tomography Staging Scheme.
Observational study in American journal of ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07095907 (Post-surgical Functional Results in Patients With Epiretinal Membrane Undergoing Controlled Macular Detachment), which is not on this map. Cited by 273 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Post-surgical Functional Results in Patients With Epiretinal Membrane Undergoing Controlled Macular Detachment: Pilot Study.
Who cites it
273 citing papers in PubMed, 504 citations in OpenAlex.
- Comparison of 27-Gauge 20,000 vs. 10,000 cuts per minute vitrectomy systems in epiretinal membrane surgery: a randomized clinical trial.Scientific reports · 2026Trial
- Effect of irrigation solution temperature during pars plana vitrectomy on early postoperative choroidal vascularity.International ophthalmology · 2026Trial
- Comparison of retinal function and macular structure after 27G pars plana vitrectomy with minimal heads-up versus standard illumination in patients with idiopathic epiretinal membranes: A pilot randomized study.Acta ophthalmologica · 2025Trial
- Influence of internal limiting membrane peeling during idiopathic epiretinal membrane removal: a randomized controlled trial.Scientific reports · 2025Trial
- Optical coherence tomography biomarkers as outcome predictors to guide dexamethasone implant use in patients with iERM: a randomized controlled trial.BMC ophthalmology · 2024Trial
- Peripheral Vascular Alterations inOphthalmology science · 2026Article
- Prediction of visual acuity by macular distortion measured with optical coherence tomography angiography in epiretinal membranes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Concurrent vitrectomy with phacoemulsification for subclinical diabetic macular edema: a long-term comparative study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Predictors of two-year visual outcomes after surgery for stage 3-4 epiretinal membrane: role of baseline vision and early retinal microstructural recovery.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Epiretinal membrane prevalence in asymmetrical pseudoexfoliation glaucoma and its impact on glaucoma monitoring parameters including peripapillary vessel density.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Surface-Specific Internal Limiting Membrane Biomechanics in Epiretinal Membrane Severity and Visual Outcomes.Investigative ophthalmology & visual science · 2026Article
- Preoperative OCT biomarkers and surgical outcomes after vitrectomy with epiretinal membrane and internal limiting membrane peeling for refractory diabetic macular edema: a retrospective cohort study.BMC ophthalmology · 2026Article
- Morphofunctional Outcomes of 3D Heads-Up Visualization Versus Standard Operating Microscopy in Idiopathic Epiretinal Membrane Surgery: A Prospective Randomized Study.Journal of clinical medicine · 2026Article
- Macula-vitreous interface vitrectomy for pediatric epiretinal membrane: surgical principles, clinical outcomes and safety profile.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Extended Depth of Field Intraocular Lens for Cataract After Vitrectomy for Retinal Detachment: A Prospective Trial.Ophthalmology and therapy · 2026Article
- The Behavior of the External Limiting Membrane and Ellipsoid Zone in Diabetic Macular Edema: A Population AI-Assisted Optical Coherence Tomography Study.Investigative ophthalmology & visual science · 2026Article
- From Subretinal to Intraretinal Fluid in Type 1 Macular Neovascularization: A Clinicopathologic Disease Transition Model.Investigative ophthalmology & visual science · 2026Article
- Dexamethasone Implant in Epiretinal Membrane Surgery: A Clinically Oriented Narrative Review of Current Evidence, Biomarkers and Patient Selection.Journal of clinical medicine · 2026Review
- Application of digital surgery in ophthalmology: intraoperative display of pre-operative enface OCT and ERM peeling unveiling the role of ERM adherence.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Evaluating ERM Stage and DRIL as predictive biomarkers for functional outcomes after iERM surgery.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
213 more citing papers are in PubMed but not listed here.
Corrections and comments
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo describe the presence of continuous ectopic inner foveal layers associated with epiretinal membranes (ERMs) and to present a new optical coherence tomography (OCT) staging system of ERMs.
designRetrospective multicenter observational case series.
methodsClinical charts and spectral-domain OCT images of 194 eyes of 172 consecutive patients diagnosed with ERMs were reviewed and analyzed.
resultsThe presence of continuous ectopic inner foveal layers was identified in 63 out of 194 eyes (32.5%) and this morphology was significantly associated with lower visual acuity. ERMs were divided into 4 stages. Stage 1 (43 out of 194 eyes, 22.1%) ERMs were mild and thin and a foveal depression was present. Stage 2 (88 out of 194 eyes, 45.4%) ERMs were associated with widening of the outer nuclear layer and loss of the foveal depression. Stage 3 (51 out of 194 eyes, 26.3%) ERMs were associated with continuous ectopic inner foveal layers crossing the entire foveal area. In stages 1, 2, and 3 all retinal layers were clearly defined on OCT. Stage 4 ERMs (12 out of 194 eyes, 6.2%) were thick and associated with continuous ectopic inner foveal layers. In addition, retinal layers were disrupted. Visual acuity progressively declined from stage 1 through stage 4 (P < .001).
conclusionsThe presence of continuous ectopic inner foveal layers in ERMs is a newly described OCT finding associated with significant vision loss and is an essential element of a novel OCT-based grading scheme of ERMs that may influence visual prognosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.