Evidence map›Paper›PMID 27993329›Full record

ArticleThe Journal of molecular diagnostics : JMD2017

An mRNA Gene Expression-Based Signature to Identify FGFR1-Amplified Estrogen Receptor-Positive Breast Tumors.

Jingqin Luo, Shuzhen Liu, Samuel Leung, Alejandro A Gru, Yu Tao, Jeremy Hoog, Julie Ho, Sherri R Davies, D Craig Allred, Andrea L Salavaggione and 4 more

Abstract read
In one paragraph

Article in The Journal of molecular diagnostics : JMD, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jingqin LuoDivision of Public Health Sciences, Washington University School of Medicine, St. Louis, Missouri; Department of Surgery, the Siteman Cancer Center Biostatistics Shared Resource, Washington University School of Medicine, St. Louis, Missouri.
Shuzhen LiuGenetic Pathology Evaluation Centre, University of British Columbia, Vancouver, British Columbia, Canada.
Samuel LeungGenetic Pathology Evaluation Centre, University of British Columbia, Vancouver, British Columbia, Canada.
Alejandro A GruDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
Yu TaoDivision of Public Health Sciences, Washington University School of Medicine, St. Louis, Missouri; Department of Surgery, the Siteman Cancer Center Biostatistics Shared Resource, Washington University School of Medicine, St. Louis, Missouri.
Jeremy HoogDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Julie HoGenetic Pathology Evaluation Centre, University of British Columbia, Vancouver, British Columbia, Canada.
Sherri R DaviesDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
D Craig AllredDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
Andrea L SalavaggioneDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
Jacqueline SniderDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
Elaine R MardisMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri.
Torsten O NielsenGenetic Pathology Evaluation Centre, University of British Columbia, Vancouver, British Columbia, Canada.
Matthew J EllisLester and Sue Smith Breast Center, Baylor School of Medicine, Houston, Texas. Electronic address: matthew.ellis@bcm.edu.

Funding

Member Site CoreU10CA180821 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI Evanthia Galanis, Olwen Hahn · 2014 to 2026
$177.3M
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Statistics CoreU10CA180882 · NCI · MAYO CLINIC ROCHESTER · PI Sumithra Jay Mandrekar · 2014 to 2026
$115.0M
THE ALLIANCE NCTN BIOREPOSITORY AND BIOSPECIMEN RESOURCEU24CA196171 · NCI · WASHINGTON UNIVERSITY · PI Mine Cicek, Wendy Frankel · 2015 to 2026
$35.0M
Biological Breast Cancer Classification by qRT-PCRU01CA114722 · NCI · WASHINGTON UNIVERSITY · PI ELLIS, MATTHEW J · 2005 to 2009
$8.7M
Washington University/ Siteman Cancer Center Lead Academic SiteU10CA180833 · NCI · WASHINGTON UNIVERSITY · PI BARTLETT, NANCY L, KOZOWER, BENJAMIN D · 2014 to 2018
$7.6M
Integrated Translational Genoproteomics Center at Washington UniversityU10CA180860 · NCI · WASHINGTON UNIVERSITY · PI CHUNG, CHRISTINE H, ELLIS, MATTHEW J · 2014 to 2018
$2.6M
NCI NIH HHS P30 CA091842NCI NIH HHS U01 CA114722NCI NIH HHS U10 CA180821NCI NIH HHS U10 CA180833NCI NIH HHS U10 CA180860NCI NIH HHS U10 CA180882NCI NIH HHS U24 CA196171
6 · The paper itself

Abstract

Fibroblast growth factor receptor 1 (FGFR1) amplification drives poor prognosis and is an emerging therapeutic target. We sought to construct a multigene mRNA expression signature to efficiently identify FGFR1-amplified estrogen receptor-positive (ER

Indexed as

Gene Expression ProfilingBiomarkers, TumorBreast NeoplasmsCohort StudiesFemaleGene AmplificationHumansKaplan-Meier EstimateProportional Hazards ModelsReceptor, Fibroblast Growth Factor, Type 1Receptors, EstrogenRNA, MessengerROC CurveTranscriptomeBiomarkers, TumorFGFR1 protein, humanReceptor, Fibroblast Growth Factor, Type 1Receptors, EstrogenRNA, Messenger

Identifiers

PMID27993329
PMCPMC5225309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.