ArticleCritical care (London, England)2016
Blood transfusion improves renal oxygenation and renal function in sepsis-induced acute kidney injury in rats.
Article in Critical care (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04194047 (Effects of Red Blood Cells Transfusion on Renal Resistivity Index and Renal Venous Stasis Index), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Red Blood Cells Transfusion on Renal Resistivity Index and Renal Venous Stasis Index
Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Blood transfusion in pediatric sepsis-associated acute kidney injury: a nationwide study of risk factors and outcomes.Pediatric nephrology (Berlin, Germany) · 2026Article
- A crucial role of miR-155 in the pathomechanism of acute kidney injury.Frontiers in pharmacology · 2025Review
- Safety of erythrocyte transfusion over a short period in pediatric patients assessed using cardiac deformation imaging.European journal of pediatrics · 2024Article
- Hemoadsorption improves kidney microcirculatory oxygenation and oxygen consumption, ameliorates tubular injury, and improves kidney function in a rat model of sepsis-induced AKI.Scientific reports · 2024Article
- Article
- Predictive value of the early postoperative hemoglobin-to-red blood cell distribution width ratio for acute kidney injury in elderly intertrochanteric fracture patients.BMC musculoskeletal disorders · 2024Article
- Being Stung Once or Twice by Bees (International journal of molecular sciences · 2024Article
- Assessing the impact of transfusion thresholds in patients with septic acute kidney injury: a retrospective study.Frontiers in medicine · 2023Article
- The role of nitric oxide in sepsis-associated kidney injury.Bioscience reports · 2022Article
- Kidney Microcirculation as a Target for Innovative Therapies in AKI.Journal of clinical medicine · 2021Review
- Low hemoglobin levels are independently associated with neonatal acute kidney injury: a report from the AWAKEN Study Group.Pediatric research · 2021Article
- Diets and Cellular-Derived Microparticles: Weighing a Plausible Link With Cerebral Small Vessel Disease.Frontiers in cardiovascular medicine · 2021Review
- Long Non-coding RNA H19 Augments Hypoxia/Reoxygenation-Induced Renal Tubular Epithelial Cell Apoptosis and Injury by the miR-130a/BCL2L11 Pathway.Frontiers in physiology · 2021Article
- The Correlation Between the Types of Initial Bacterial Infection and Clinical Prognosis in Patients With Septic AKI.Frontiers in medicine · 2021Article
- MiR-22-3p suppresses sepsis-induced acute kidney injury by targeting PTEN.Bioscience reports · 2020Article
- Using arterial-venous oxygen difference to guide red blood cell transfusion strategy.Critical care (London, England) · 2020Observational
- Microcirculation: Physiology, Pathophysiology, and Clinical Application.Blood purification · 2020Review
- Relationship between hemoglobin levels and vancomycin clearance in patients with sepsis.European journal of clinical pharmacology · 2019Article
- Early treatment with GLP-1 after severe trauma preserves renal function in obese Zucker rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Acute Kidney Injury and Fluid Resuscitation in Septic Patients: Are We Protecting the Kidney?Nephron · 2019Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effects of blood transfusion on renal microcirculation during sepsis are unknown. This study aimed to investigate the effect of blood transfusion on renal microvascular oxygenation and renal function during sepsis-induced acute kidney injury.
methodsTwenty-seven Wistar albino rats were randomized into four groups: a sham group (n = 6), a lipopolysaccharide (LPS) group (n = 7), a LPS group that received fluid resuscitation (n = 7), and a LPS group that received blood transfusion (n = 7). The mean arterial blood pressure, renal blood flow, and renal microvascular oxygenation within the kidney cortex were recorded. Acute kidney injury was assessed using the serum creatinine levels, metabolic cost, and histopathological lesions. Nitrosative stress (expression of endothelial (eNOS) and inducible nitric oxide synthase (iNOS)) within the kidney was assessed by immunohistochemistry. Hemoglobin levels, pH, serum lactate levels, and liver enzymes were measured.
resultsFluid resuscitation and blood transfusion both significantly improved the mean arterial pressure and renal blood flow after LPS infusion. Renal microvascular oxygenation, serum creatinine levels, and tubular damage significantly improved in the LPS group that received blood transfusion compared to the group that received fluids. Moreover, the renal expression of eNOS was markedly suppressed under endotoxin challenge. Blood transfusion, but not fluid resuscitation, was able to restore the renal expression of eNOS. However, there were no significant differences in lactic acidosis or liver function between the two groups.
conclusionsBlood transfusion significantly improved renal function in endotoxemic rats. The specific beneficial effect of blood transfusion on the kidney could have been mediated in part by the improvements in renal microvascular oxygenation and sepsis-induced endothelial dysfunction via the restoration of eNOS expression within the kidney.
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