ArticleJournal of nanobiotechnology2016
Biodistribution of biodegradable polymeric nano-carriers loaded with busulphan and designed for multimodal imaging.
Article in Journal of nanobiotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 35 citations in OpenAlex.
- Nanoparticle Detection in Biology and Medicine: A Review.Biosensors · 2025Review
- Collagen-targeted protein nanomicelles for the imaging of non-alcoholic steatohepatitis.Acta biomaterialia · 2024Article
- Engineered smart materials for RNA based molecular therapy to treat Glioblastoma.Bioactive materials · 2024Article
- Molecular homing and retention of muscle membrane stabilizing copolymers by non-invasive optical imaging in vivo.Molecular therapy. Methods & clinical development · 2023Article
- Advances in biomarkers and techniques for pancreatic cancer diagnosis.Cancer cell international · 2022Review
- In Vivo Distribution of Poly(ethylene glycol) Functionalized Iron Oxide Nanoclusters: An Ultrastructural Study.Nanomaterials (Basel, Switzerland) · 2021Article
- Systemically Delivered Magnetic Hyperthermia for Prostate Cancer Treatment.Pharmaceutics · 2020Article
- Intermittent time-set technique controlling the temperature of magnetic-hyperthermia-ablation for tumor therapy.RSC advances · 2018Article
- Advantages and Limitations of Current Techniques for Analyzing the Biodistribution of Nanoparticles.Frontiers in pharmacology · 2018Review
- Magnetic polymeric nanoassemblies for magnetic resonance imaging-combined cancer theranostics.International journal of nanomedicine · 2018Review
- Biodistribution of arctigenin-loaded nanoparticles designed for multimodal imaging.Journal of nanobiotechnology · 2017Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultifunctional nanocarriers for controlled drug delivery, imaging of disease development and follow-up of treatment efficacy are promising novel tools for disease diagnosis and treatment. In the current investigation, we present a multifunctional theranostic nanocarrier system for anticancer drug delivery and molecular imaging. Superparamagnetic iron oxide nanoparticles (SPIONs) as an MRI contrast agent and busulphan as a model for lipophilic antineoplastic drugs were encapsulated into poly (ethylene glycol)-co-poly (caprolactone) (PEG-PCL) micelles via the emulsion-evaporation method, and PEG-PCL was labelled with VivoTag 680XL fluorochrome for in vivo fluorescence imaging.
resultsBusulphan entrapment efficiency was 83% while the drug release showed a sustained pattern over 10 h. SPION loaded-PEG-PCL micelles showed contrast enhancement in T
conclusionsThus, with loaded contrast agent and conjugated fluorochrome, PEG-PCL micelles as biodegradable and biocompatible nanocarriers are efficient multimodal imaging agents, offering high drug loading capacity, and sustained drug release. These might offer high treatment efficacy and real-time tracking of the drug delivery system in vivo, which is crucial for designing of an efficient drug delivery system.
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