ArticleAging2016
Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis.
Open access · hybridAbstract read
In one paragraph
Article in Aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 109 citations in OpenAlex.
- Senescence intensifies bleomycin-induced injury in idiopathic pulmonary fibrosis lung epithelial cells.ERJ open research · 2026Article
- Melanoma and its fibroblastic allies: the emerging importance of CAFs in immune suppression, ECM modulation, and therapy resistance.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Stromal senescence contributes to age-related increases in cancer.Nature reviews. Cancer · 2025Review
- Cells of all trades - on the importance of spatial positioning of senescent cells in development, healing and aging.FEBS letters · 2025Review
- Best evidence linking the extracellular factor TGF-β to cancer-associated alternative splicing programs.BBA advances · 2025Review
- The multifaceted role of the stroma in the healthy prostate and prostate cancer.Journal of translational medicine · 2024Review
- Fibroblast senescence-associated extracellular matrix promotes heterogeneous lung niche.APL bioengineering · 2024Article
- Rosarugosides A and D fromPlants (Basel, Switzerland) · 2024Article
- Fibroblasts from HPV-negative oropharynx squamous cell carcinomas stimulate the release of osteopontin from cancer cells via the release of IL-6.Frontiers in oral health · 2024Article
- Systematic transcriptomic analysis and temporal modelling of human fibroblast senescence.Frontiers in aging · 2024Article
- Article
- Identification of AOC3 and LRRC17 as Colonic Fibroblast Activation Markers and Their Potential Roles in Colorectal Cancer Progression.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Review
- Pericentromeric satellite lncRNAs are induced in cancer-associated fibroblasts and regulate their functions in lung tumorigenesis.Cell death & disease · 2023Article
- Aging and oral squamous cell carcinoma development: the role of cellular senescence.Frontiers in oral health · 2023Review
- Article
- Cancer-Associated Fibroblast Heterogeneity, Activation and Function: Implications for Prostate Cancer.Biomolecules · 2022Review
- ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance.Cancer research · 2022Article
- Therapy-Induced Stromal Senescence Promoting Aggressiveness of Prostate and Ovarian Cancer.Cells · 2022Article
- Tumor-stroma ratio can predict lymph-node metastasis in cT1/2N0 oral tongue squamous cell carcinoma independent of tumor budding grade.International journal of clinical oncology · 2022Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 8 institutions in 3 countries.
Massimiliano MelloneCancer Sciences Unit, Faculty of Medicine, University of Southampton, SO166YD, UK.
Christopher J HanleyCancer Sciences Unit, Faculty of Medicine, University of Southampton, SO166YD, UK.
Steve ThirdboroughCancer Sciences Unit, Faculty of Medicine, University of Southampton, SO166YD, UK.
Toby MellowsCancer Sciences Unit, Faculty of Medicine, University of Southampton, SO166YD, UK.
Edwin GarciaCancer Sciences Unit, Faculty of Medicine, University of Southampton, SO166YD, UK.
Jeongmin WooFaculty of Medicine, University of Southampton, Southampton SO166YD, UK.
Joanne TodCancer Sciences Unit, Faculty of Medicine, University of Southampton, SO166YD, UK.
Steve FramptonCancer Sciences Unit, Faculty of Medicine, University of Southampton, SO166YD, UK.
Veronika JeneiCancer Sciences Unit, Faculty of Medicine, University of Southampton, SO166YD, UK.
Karwan A MoutasimCancer Sciences Unit, Faculty of Medicine, University of Southampton, SO166YD, UK.
Tasnuva D KabirIntegrated Biosciences, School of Clinical Dentistry, University of Sheffield, Sheffield S102TA, UK.
Peter A BrennanQueen Alexandra Hospital, Portsmouth Hospitals NHS Trust, Portsmouth PO63LY, UK.
Giulia VenturiCancer Sciences Unit, Faculty of Medicine, University of Southampton, SO166YD, UK.
Kirsty FordCancer Sciences Unit, Faculty of Medicine, University of Southampton, SO166YD, UK.
Nicolas HerranzMRC Clinical Sciences Centre, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, London W12, UK.
Kue Peng LimCancer Research Initiatives Foundation. Sime Darby Medical Centre, Subang Jaya, Selangor 47500, Malaysia.
James ClarkeCancer Sciences Unit, Faculty of Medicine, University of Southampton, SO166YD, UK.
Daniel W LambertIntegrated Biosciences, School of Clinical Dentistry, University of Sheffield, Sheffield S102TA, UK.
Stephen S PrimeCentre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E12AD, UK.
Timothy J UnderwoodCancer Sciences Unit, Faculty of Medicine, University of Southampton, SO166YD, UK.
Pandurangan VijayanandLa Jolla Institute for Allergy & Immunology, La Jolla, California 92037, USA.
Kevin W EliceiriLaboratory for Optical and Computational Instrumentation (LOCI), Department of Biomedical Engineering, University of Madison, Wisconsin, WI 53706, USA.
Christopher WoelkFaculty of Medicine, University of Southampton, Southampton SO166YD, UK.
Emma V KingCancer Sciences Unit, Faculty of Medicine, University of Southampton, SO166YD, UK.
Jesus GilMRC Clinical Sciences Centre, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, London W12, UK.
Christian H OttensmeierCancer Sciences Unit, Faculty of Medicine, University of Southampton, SO166YD, UK.
Gareth J ThomasCancer Sciences Unit, Faculty of Medicine, University of Southampton, SO166YD, UK.
University of Southampton · GBHammersmith Hospital · GBUniversity of Sheffield · GBCancer Research Malaysia · MYLa Jolla Institute for Immunology · USQueen Alexandra Hospital · GBQueen Mary University of London · GBUniversity of Wisconsin–Madison · US
Funding
Illumina HiSeq 2500 Sequencing SystemS10OD016262 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI RAO, ANJANA · 2013 to 2013
$600kCancer Research UK 15951Cancer Research UK 18892Cancer Research UK 20613Cancer Research UK 22795Cancer Research UK C21825/A13315Medical Research Council G1002565Medical Research Council MC_U120085810NIH HHS S10 OD016262
Abstract
Cancer-associated fibroblasts (CAF) remain a poorly characterized, heterogeneous cell population. Here we characterized two previously described tumor-promoting CAF sub-types, smooth muscle actin (SMA)-positive myofibroblasts and senescent fibroblasts, identifying a novel link between the two. Analysis of CAF cultured
Indexed as
AnimalsCell DifferentiationCell Line, TumorCellular SenescenceExtracellular MatrixFibroblastsHumansMiceMyofibroblastsNeoplasmsPhenotypePrognosisSignal TransductionTransforming Growth Factor beta1Transforming Growth Factor beta1collagenextracellular matrixmyofibroblastssenescencesenescent fibroblaststumor microenvironment
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.