ArticlePsychiatry research. Neuroimaging2017
Brain network dysfunction in youth with obsessive-compulsive disorder induced by simple uni-manual behavior: The role of the dorsal anterior cingulate cortex.
Article in Psychiatry research. Neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Common abnormality of gray matter integrity in substance use disorder and obsessive-compulsive disorder: A comparative voxel-based meta-analysis.Human brain mapping · 2021Pooled it
- Cross-Sectional Mega-Analysis of Resting-State Alterations Associated with Autism and Attention-Deficit/Hyperactivity Disorder in Children and Adolescents.Nature. Mental health · 2025Article
- The importance of covert memory consolidation in schizophrenia: Dysfunctional network profiles of the hippocampus and the dorsolateral prefrontal cortex.Psychiatry research. Neuroimaging · 2024Article
- Neurocircuitry of Contingency Awareness in Pavlovian Fear Conditioning.Cognitive, affective & behavioral neuroscience · 2021Article
- Microstructure of Human Corpus Callosum across the Lifespan: Regional Variations in Axon Caliber, Density, and Myelin Content.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Evoking network profiles of the dorsal anterior cingulate in youth with Obsessive-Compulsive Disorder during motor control and working memory.Journal of psychiatric research · 2021Article
- Functional Brain Imaging and OCD.Current topics in behavioral neurosciences · 2021Review
- Breakdown of the affective-cognitive network in functional dystonia.Human brain mapping · 2020Article
- MRI Insights Into Adolescent Neurocircuitry-A Vision for the Future.Frontiers in human neuroscience · 2020Article
- The Neurocircuitry Underlying Additive Effects of Safety Instruction on Extinction Learning.Frontiers in behavioral neuroscience · 2020Article
- A data mining approach for classification of orthostatic and essential tremor based on MRI-derived brain volume and cortical thickness.Annals of clinical and translational neurology · 2019Article
- Cortical-hippocampal functional connectivity during covert consolidation sub-serves associative learning: Evidence for an active "rest" state.Brain and cognition · 2019Article
- Response Hand and Motor Set Differentially Modulate the Connectivity of Brain Pathways During Simple Uni-manual Motor Behavior.Brain topography · 2018Article
- Activations in gray and white matter are modulated by uni-manual responses during within and inter-hemispheric transfer: effects of response hand and right-handedness.Brain imaging and behavior · 2018Article
- Distinct Neurobehavioral Mechanisms for Expectancy Violation and Value Updating.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Motor system dysfunction in the schizophrenia diathesis: Neural systems to neurotransmitters.European psychiatry : the journal of the Association of European Psychiatrists · 2017Review
- Hyper-modulation of brain networks by the amygdala among women with Borderline Personality Disorder: Network signatures of affective interference during cognitive processing.Journal of psychiatric research · 2017Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
In an effort to elucidate differences in functioning brain networks between youth with obsessive-compulsive disorder and controls, we used fMRI signals to analyze brain network interactions of the dorsal anterior cingulate cortex (dACC) during visually coordinated motor responses. Subjects made a uni-manual response to briefly presented probes, at periodic (allowing participants to maintain a "motor set") or random intervals (demanding reactive responses). Network interactions were assessed using psycho-physiological interaction (PPI), a basic model of functional connectivity evaluating modulatory effects of the dACC in the context of each task condition. Across conditions, OCD were characterized by hyper-modulation by the dACC, with loci alternatively observed as both condition-general and condition-specific. Thus, dynamically driven task demands during simple uni-manual motor control induce compensatory network interactions in cortical-thalamic regions in OCD. These findings support previous research in OCD showing compensatory network interactions during complex memory tasks, but establish that these network effects are observed during basic sensorimotor processing. Thus, these patterns of network dysfunction may in fact be independent of the complexity of tasks used to induce brain network activity. Hypothesis-driven approaches coupled with sophisticated network analyses are a highly valuable approach in using fMRI to uncover mechanisms in disorders like OCD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.