ArticleClinical and experimental otorhinolaryngology2017
Usefulness of Allerkin House Dust Mite Extract for Nasal Provocation Testing.
Article in Clinical and experimental otorhinolaryngology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Utility of silver birch and house dust mite extracts derived from licensed sublingual tablets for nasal allergen challenge.Clinical and translational allergy · 2024Article
- Selection of allergen extract for immunotherapy in polysensitized allergic rhinitis patients.Immunotherapy · 2024Article
- Korean Modification of the Nasal Provocation Test With House Dust Mite Antigen Following the EAACI Guidelines.Clinical and experimental otorhinolaryngology · 2021Article
- Appropriate Antigen Concentrations and Timing of a Nasal Provocation Test.Yonsei medical journal · 2021Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe evaluated the clinical usefulness of Allerkin (Lofarma) for nasal provocation testing (NPT) in patients with rhinitis symptoms, by examining changes in nasal symptoms and acoustic parameters after exposure to house dust mite (HDM) extract.
methodsTwenty patients (16 males and 4 females, mean age: 29.6±14.6 years) were enrolled. We performed skin prick test (SPT) before and 15 and 30 minutes after intranasal challenge with Allerkin HDM extract, and we evaluated symptom changes (nasal obstruction, rhinorrhea, sneezing, and itching) using a visual analogue scale. We also evaluated changes in acoustic parameters such as total nasal volume (TNV) and minimal cross-sectional area (MCA) before and after challenge.
resultsGroup A (the nonallergic group, n=8) showed negative results for all tested aeroallergens in SPT and nonprovocative results (<25% decrease of TNV and MCA from the baseline value) in NPT. Group B (the allergic group, n=7) exhibited strongly positive results (wheal size larger than that of histamine) for HDM allergens on SPT. Group C (the local allergic group, n=5) showed negative results on SPT, but a provocative response on NPT (>29% decrease in TNV/MCA from the baseline value). Patients in group C showed significant aggravation of nasal obstruction compared to those in group A (
conclusionAllerkin HDM extract can be a useful provocative agent in NPT for diagnosing allergic rhinitis and local allergic rhinitis.
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