Evidence map›Paper›PMID 27992300›Full record

ArticleJournal of laparoendoscopic & advanced surgical techniques. Part A2017

Identification of the Lymphatic Drainage Pattern of Esophageal Cancer with Near-Infrared Fluorescent Imaging.

Francisco Schlottmann, Arianna Barbetta, Benedetto Mungo, Anne O Lidor, Daniela Molena

Registry-linked trialOpen access · greenAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of laparoendoscopic & advanced surgical techniques. Part A, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04107623 (Quantitative Fluorescent Guided Robotic Surgery for Cancer of the Gastroesophageal Junction), which is not on this map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04107623 nacompletednot on this mapstarted 2020, after this paper: background citation

Quantitative Fluorescent Guided Robotic Surgery for Cancer of the Gastroesophageal Junction

TypeinterventionalSponsorRigshospitalet, DenmarkRan2020 to 2021Enrolled70ConditionsStomach Neoplasms, SurgeryArmsIndocyanine Green
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 45 citations in OpenAlex.

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  18. Fluorescence-guided surgery of the esophagus.Annals of translational medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Francisco Schlottmann1 Thoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Arianna Barbetta1 Thoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Benedetto Mungo2 Department of Surgery, Johns Hopkins University School of Medicine , Baltimore, Maryland.
Anne O Lidor3 Department of Surgery, University of Wisconsin , Madison, Wisconsin.
Daniela Molena1 Thoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Memorial Sloan Kettering Cancer Center · USJohns Hopkins University · USUniversity of Wisconsin–Madison · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

objectiveNodal status is one of the most important long-term prognostic factors for esophageal cancer. The aim of this study was to evaluate the ability of near-infrared (NIR) light fluorescent imaging to identify the lymphatic drainage pattern of esophageal cancer.

methodsPatients with distal esophageal cancer or esophagogastric junction cancer scheduled for esophagectomy were enrolled in this study. Before surgery, an endoscopy was performed with submucosal injection of 2 cc of indocyanine green (ICG) around the tumor. Real-time NIR images from the surgical field were obtained for each patient to visualize the lymphatic ICG drainage.

resultsA total of nine patients were included in this study. Ivor Lewis esophagectomy was performed in all cases. ICG drainage was visualized to first drain along the left gastric nodes in eight patients (88.9%) and toward the diaphragmatic nodes in one patient (11.1%). The median number of resected nodes was 32. Three patients (33.3%) presented nodal involvement. All of them had positive nodes in the first nodal station identified with ICG.

conclusionsEvaluation of the lymphatic drainage pattern with real-time NIR light fluorescent technique is feasible. Distal and esophagogastric junction tumors showed to drain first in the left gastric nodes in most of the cases.

Indexed as

Spectroscopy, Near-InfraredAdenocarcinomaAdultCarcinoma, Squamous CellEsophageal NeoplasmsEsophagectomyFeasibility StudiesFluorescent DyesHumansIndocyanine GreenLymphatic MetastasisLymphatic VesselsLymph Node ExcisionLymph NodesOptical ImagingPilot ProjectsFluorescent DyesIndocyanine Greenesophageal cancerlymphatic drainagenear-infrared imaging

Identifiers

PMID27992300
PMCPMC5583563
OpenAlexW2563864662

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.