ReviewNeuromodulation : journal of the International Neuromodulation Society2017
Posttraumatic Stress Disorder: Perspectives for the Use of Deep Brain Stimulation.
Review in Neuromodulation : journal of the International Neuromodulation Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Deep Brain Stimulation in Treatment-Resistant Psychiatric Disorders: Efficacy, Safety, and Future Directions.Brain sciences · 2025Review
- The problem of moral obligation to preserve or erase memories in trauma treatment.Philosophy, ethics, and humanities in medicine : PEHM · 2025Article
- The case for hemispheric lateralization of the human amygdala in fear processing.Molecular psychiatry · 2025Article
- Epitranscriptomic Analysis of the Ventral Hippocampus in a Mouse Model of Post-Traumatic Stress Disorder Following Deep Brain Stimulation Treatment of the Basolateral Amygdala.Brain sciences · 2025Article
- Review
- To Predict, Prevent, and Manage Post-Traumatic Stress Disorder (PTSD): A Review of Pathophysiology, Treatment, and Biomarkers.International journal of molecular sciences · 2023Review
- The Effects of Prenatal Dexamethasone Exposure on Brain Metabolic Homeostasis in Adulthood: Implications for Depression.International journal of molecular sciences · 2023Article
- Enhancing Psychological Interventions for Post-Traumatic Stress Disorder (PTSD) Treatment with Memory Influencing Drugs.Current neuropharmacology · 2023Review
- Contemporary Approaches Toward Neuromodulation of Fear Extinction and Its Underlying Neural Circuits.Current topics in behavioral neurosciences · 2023Article
- Deep brain stimulation of the subgenual cingulum and uncinate fasciculus for the treatment of posttraumatic stress disorder.Science advances · 2022Article
- Post-traumatic stress disorder: a psychiatric disorder requiring urgent attention.Medical review (2021) · 2022Review
- Memory-directed acupuncture as a neuromodulatory treatment for PTSD: Theory, clinical model and case studies.Translational psychiatry · 2022Review
- Elevated activity in the dorsal dentate gyrus reduces expression of fear memory after fear extinction training.Journal of psychiatry & neuroscience : JPN · 2021Article
- Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons.Molecular psychiatry · 2019Article
- Beyond Emotions: Oscillations of the Amygdala and Their Implications for Electrical Neuromodulation.Frontiers in neuroscience · 2019Review
- Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man.Nature reviews. Neuroscience · 2018Review
- Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder.Molecular neurobiology · 2018Review
- DBS in Treatment of Post-Traumatic Stress Disorder.Brain sciences · 2018Review
- Post-Traumatic Stress Disorder Delineating the Progression and Underlying Mechanisms Following Blast Traumatic Brain Injury.Journal of neuroscience and neuropharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesDeep Brain Stimulation (DBS) has been either approved or is currently under investigation for a number of psychiatric disorders. MATERIALS AND
methodsWe review clinical and preclinical concepts as well as the neurocircuitry that may be of relevance for the implementation of DBS in posttraumatic stress disorder (PTSD).
resultsPTSD is a chronic and debilitating illness associated with dysfunction in well-established neural circuits, including the amygdala and prefrontal cortex. Although most patients often improve with medications and/or psychotherapy, approximately 20-30% are considered to be refractory to conventional treatments. In other psychiatric disorders, DBS has been investigated in treatment-refractory patients. To date, preclinical work suggests that stimulation at high frequency delivered at particular timeframes to different targets, including the amygdala, ventral striatum, hippocampus, and prefrontal cortex may improve fear extinction and anxiety-like behavior in rodents. In the only clinical report published so far, a patient implanted with electrodes in the amygdala has shown striking improvements in PTSD symptoms.
conclusionsNeuroimaging, preclinical, and preliminary clinical data suggest that the use of DBS for the treatment of PTSD may be practical but the field requires further investigation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.