ArticleNature neuroscience2017
Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes.
Article in Nature neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 265 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
265 citing papers in PubMed, 1 synthesis or guideline pooled it, 525 citations in OpenAlex.
- Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways.Nature genetics · 2022Pooled it
- Beyond Pleasure: Unraveling the Multifaceted Role of Dopamine in Obesity and Metabolic Regulation.Current obesity reports · 2026Review
- Scalable hypothalamic neuron differentiation from human pluripotent stem cells suitable for modeling metabolic disorders.Stem cell reports · 2026Article
- Mapping of oxytocin- and arginine vasopressin-expressing neurons with calbindin 1 or reelin in the male mouse brain.Journal of neuroendocrinology · 2026Article
- Single-Nucleus Transcriptomics of the Mouse Medial Preoptic Area Reveals Sex-Dependent Molecular Signatures of Social Dominance.bioRxiv : the preprint server for biology · 2026Article
- Self-supervised graph contrastive learning for scRNA-seq clustering.Journal of translational medicine · 2026Article
- scIMGCN: an Automatic Single-Cell Type Annotation Method Based on Interpretable Graph Convolutional Network.Interdisciplinary sciences, computational life sciences · 2026Article
- Interpretable Multi-task Analysis of Single-Cell RNA-seq Data Through Topological Structure Preservation and Data Denoising.Interdisciplinary sciences, computational life sciences · 2026Article
- scSCCNIA: similarity matrix based contrastive clustering with neighbor information aggregation for single-cell RNA sequencing data.Briefings in bioinformatics · 2026Article
- Alk-Fam150b (augmentor α) expression in the paraventricular nucleus of the mouse hypothalamus at molecular resolution, and its sensitivity to acute stress.Journal of neuroendocrinology · 2026Article
- scAURA: Alignment- and Uniformity-based Graph Debiased Contrastive Representation Architecture for Self-Supervised Clustering of Single-Cell Transcriptomics.bioRxiv : the preprint server for biology · 2026Article
- Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons.Current biology : CB · 2026Article
- Development of the neurohypophysis: A major neuroendocrine interface.Journal of neuroendocrinology · 2026Review
- The ventrolateral preoptic nucleus: a multisystem integrator in sleep-wake regulation.Frontiers in neuroscience · 2026Review
- scANMF: Prior Knowledge and Graph-Regularized NMF for Accurate Cell Type Annotation in scRNA-seq.International journal of molecular sciences · 2025Article
- Article
- Effects of uniform rocking motion on VLPO regional GABA/Glu contents and sleep in rats.Sleep and biological rhythms · 2025Article
- BiAEImpute: a robust bidirectional autoencoder framework for High-fidelity dropout imputation in single-cell transcriptomics.BMC genomics · 2025Article
- Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons.bioRxiv : the preprint server for biology · 2025Article
- scVGAMF: a novel imputation method for scRNA-seq data by integrating linear and non-linear features.Briefings in bioinformatics · 2025Article
205 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
31 authors at 13 institutions in 8 countries.
Funding
Abstract
The hypothalamus contains the highest diversity of neurons in the brain. Many of these neurons can co-release neurotransmitters and neuropeptides in a use-dependent manner. Investigators have hitherto relied on candidate protein-based tools to correlate behavioral, endocrine and gender traits with hypothalamic neuron identity. Here we map neuronal identities in the hypothalamus by single-cell RNA sequencing. We distinguished 62 neuronal subtypes producing glutamatergic, dopaminergic or GABAergic markers for synaptic neurotransmission and harboring the ability to engage in task-dependent neurotransmitter switching. We identified dopamine neurons that uniquely coexpress the Onecut3 and Nmur2 genes, and placed these in the periventricular nucleus with many synaptic afferents arising from neuromedin S
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.