ArticleThe Journal of clinical investigation2017
Gsα deficiency in the dorsomedial hypothalamus underlies obesity associated with Gsα mutations.
Article in The Journal of clinical investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Recent developments in GPCR signalling in appetite regulation.Bioscience reports · 2026Review
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- A human obesity-associated MC4R mutation with defective Gq/11α signaling leads to hyperphagia in mice.The Journal of clinical investigation · 2024Article
- Explorative research on glucolipid metabolism and levels of adipokines in pseudohypoparathyroidism type 1 patients.Orphanet journal of rare diseases · 2023Article
- Article
- Parental Origin ofJBMR plus · 2022Article
- GAmerican journal of physiology. Endocrinology and metabolism · 2021Article
- Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control.Frontiers in physiology · 2021Review
- Recent advances in understanding the role of leptin in energy homeostasis.F1000Research · 2020Review
- Article
- Management of pseudohypoparathyroidism.Current opinion in pediatrics · 2019Review
- GMolecular metabolism · 2019Article
- The melanocortin pathway and control of appetite-progress and therapeutic implications.The Journal of endocrinology · 2019Review
- Disruption of brain-derived neurotrophic factor production from individual promoters generates distinct body composition phenotypes in mice.American journal of physiology. Endocrinology and metabolism · 2018Article
- Glucose Homeostasis and Energy Balance in Children With Pseudohypoparathyroidism.The Journal of clinical endocrinology and metabolism · 2018Article
- Genetic and Epigenetic Defects at the GNAS Locus Lead to Distinct Patterns of Skeletal Growth but Similar Early-Onset Obesity.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Article
- The stimulatory G protein GThe Journal of biological chemistry · 2018Article
- Central regulation of brown adipose tissue thermogenesis and energy homeostasis dependent on food availability.Pflugers Archiv : European journal of physiology · 2018Review
- GNAS mutations and heterotopic ossification.Bone · 2018Review
- Biased signaling at neural melanocortin receptors in regulation of energy homeostasis.Biochimica et biophysica acta. Molecular basis of disease · 2017Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Gsα, encoded by Gnas, mediates hormone and neurotransmitter receptor-stimulated cAMP generation. Heterozygous Gsα-inactivating mutations lead to obesity in Albright hereditary osteodystrophy (AHO) patients, but only when the mutations occur on the maternal allele. This parent-of-origin effect is due to Gsα imprinting in the CNS, although the relevant CNS regions are unknown. We have now shown that mice with a Gnas gene deletion disrupting Gsα expression on the maternal allele, but not the paternal allele, in the dorsomedial nucleus of the hypothalamus (DMH) developed obesity and reduced energy expenditure without hyperphagia. Although maternal Gnas deletion impaired activation of brown adipose tissue (BAT) in mice, their responses to cold environment remained intact. Similar findings were observed in mice with DMH-specific deficiency of melanocortin MC4R receptors, which are known to activate Gsα. Our results show that Gsα imprinting in the DMH underlies the parent-of-origin metabolic phenotype that results from Gsα mutations and that DMH MC4R/Gsα signaling is important for regulation of energy expenditure and BAT activation, but not the metabolic response to cold.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.