ArticleeLife2016
Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 1 pooled it
10.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- Utero-placental calcium and magnesium ion channels: A systematic review of obstetric implications of their alterations.Channels (Austin, Tex.) · 2026Pooled it
- Placental TRPV2 supports trophoblast function and normal fetal development.Nature communications · 2026Article
- Renal TRPM6 but not Kv1.1 is required for magnesium homeostasis in mice.American journal of physiology. Renal physiology · 2026Article
- Magnesium as a Bioenergetic Checkpoint Linking Mitochondrial Function, Metabolic Disease, and Aging.Aging cell · 2026Review
- Dolutegravir developmental toxicity is mitigated by magnesium and folate in zebrafish embryos.Disease models & mechanisms · 2026Article
- Evolution in metazoans of the TRPM channel family involves multiple gains and losses of genes and domains.Molecular biology and evolution · 2026Article
- Chronic magnesium supplementation in a patient with relapsing severe hypomagnesaemia due to a novelBMJ case reports · 2026Article
- Dapagliflozin-Associated Resolution of Acute Carboplatin-Induced Hypomagnesemia-Exploration of TRPM6/7 Channel Activity.Kidney international reports · 2025Article
- Physiological functions and pharmacological targeting of transient receptor potential channels.Pharmacological reviews · 2025Review
- TRPM6 in murine kidneys-of targets and antibodies.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- TRPM7 underlies cadmium cytotoxicity in pulmonary cells.Archives of toxicology · 2025Article
- A distal convoluted tubule-specific isoform of murine SLC41A3 extrudes magnesium.Acta physiologica (Oxford, England) · 2025Article
- The PACT Network: PRL, ARL, CNNM, and TRPM Proteins in Magnesium Transport and Disease.International journal of molecular sciences · 2025Review
- Characterization of intestine-specific TRPM6 knockout C57BL/6 J mice: effects of short-term omeprazole treatment.Pflugers Archiv : European journal of physiology · 2025Article
- Article
- Genetic drivers of age-related changes in urinary magnesium excretion.Physiological genomics · 2024Article
- Magnesium: A Defense Line to Mitigate Inflammation and Oxidative Stress in Adipose Tissue.Antioxidants (Basel, Switzerland) · 2024Review
- Structural basis of selective TRPM7 inhibition by the anticancer agent CCT128930.Cell reports · 2024Article
- TRPM channels in health and disease.Nature reviews. Nephrology · 2024Review
- Essential role of MgCell reports · 2023Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 9 institutions in 4 countries.
Vladimir ChubanovWalther-Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Munich, Germany.ORCID 0000-0002-6042-4193
Silvia FerioliWalther-Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Munich, Germany.
Annika WisnowskyWalther-Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Munich, Germany.
David G SimmonsSchool of Biomedical Sciences, The University of Queensland, Brisbane, Australia.ORCID 0000-0002-4115-9371
Christin LeitzingerInstitute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum Munich, Neuherberg, Germany.
Claudia EinerInstitute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum Munich, Neuherberg, Germany.
Wenke JonasDepartment of Experimental Diabetology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany.
Yuriy ShymkivPrinceton Institute of Life Sciences, Princeton, United States.
Harald BartschInstitute of Pathology, Ludwig Maximilian University of Munich, Munich, Germany.
Attila BraunRudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany.
Banu AkdoganWalther-Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Munich, Germany.
Lorenz MittermeierWalther-Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Munich, Germany.
Ludmila SytikWalther-Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Munich, Germany.
Friedrich TorbenGenome Analysis Center, Institute of Experimental Genetics, Helmholtz Zentrum Munich, Neuherberg, Germany.
Vindi JurinovicInstitute for Medical Informatics, Biometry and Epidemiology, Ludwig Maximilian University of Munich, Munich, Germany.
Emiel Pc van der VorstInstitute for Cardiovascular Prevention, Ludwig Maximilian University of Munich, Munich, Germany.
Christian WeberInstitute for Cardiovascular Prevention, Ludwig Maximilian University of Munich, Munich, Germany.
Önder A YildirimComprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum Munich, Neuherberg, Germany.
Karl SotlarInstitute of Pathology, Ludwig Maximilian University of Munich, Munich, Germany.
Annette SchürmannDepartment of Experimental Diabetology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany.
Susanna ZierlerWalther-Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Munich, Germany.ORCID 0000-0002-4684-0385
Hans ZischkaInstitute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum Munich, Neuherberg, Germany.
Alexey G RyazanovPrinceton Institute of Life Sciences, Princeton, United States.
Thomas GudermannWalther-Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Munich, Germany.
Ludwig-Maximilians-Universität München · DEHelmholtz Zentrum München · DEDeutsches Diabetes-Zentrum e.V. · DEGerman Centre for Cardiovascular Research · DEParacelsus Medical University · ATPrinceton University · USRutgers, The State University of New Jersey · USThe University of Queensland · AUUniversity of Würzburg · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mg
Indexed as
Embryonic DevelopmentAnimalsFemaleGene Knockout TechniquesIntestinal MucosaMagnesiumMicePlacentaPregnancySurvival AnalysisTRPM Cation ChannelsYolk SacMagnesiumTrpm6 protein, mouseTRPM Cation Channelsbiophysicshuman biologyintestinekidneylongevitymagnesiummedicinemouseplacentastructural biologytrophoblast stem cells
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.