ArticleAnalytical chemistry2017
The "PepSAVI-MS" Pipeline for Natural Product Bioactive Peptide Discovery.
Article in Analytical chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Topographic imaging with automatic z-axis correction of Brassica oleracea var. viridis leaves by IR-MALDESI mass spectrometry imaging.Analytical and bioanalytical chemistry · 2025Article
- Review
- Identification and Characterization of CC-AMP1-like and CC-AMP2-like Peptides inJournal of proteome research · 2024Article
- Plant peptides - redefining an area of ribosomally synthesized and post-translationally modified peptides.Natural product reports · 2024Review
- Characterization and evaluation of cytotoxic and antimicrobial activities of cyclotides from Viola japonica.Scientific reports · 2024Article
- The Greater Celandine: Identification and Characterization of an Antimicrobial Peptide fromJournal of natural products · 2024Article
- Integrating High-Resolution Mass Spectral Data, Bioassays and Computational Models to Annotate Bioactives in Botanical Extracts: Case Study Analysis ofMolecules (Basel, Switzerland) · 2024Article
- An Update on the Therapeutic Potential of Antimicrobial Peptides againstPharmaceuticals (Basel, Switzerland) · 2023Review
- Targeted Large-Scale Genome Mining and Candidate Prioritization for Natural Product Discovery.Marine drugs · 2022Review
- Creating optimized peptide libraries for AMP discovery via PepSAVI-MS.Methods in enzymology · 2022Article
- Cyclotide-rich fractions containing nanofibers by electrospinning: preparation, characterization and examination of antimicrobial activity.Turkish journal of chemistry · 2022Article
- In silico prediction and mass spectrometric characterization of botanical antimicrobial peptides.Methods in enzymology · 2022Article
- Mass Spectrometric Identification of Antimicrobial Peptides from Medicinal Seeds.Molecules (Basel, Switzerland) · 2021Article
- Too Hot to Handle: Antibacterial Peptides Identified in Ghost Pepper.Journal of natural products · 2021Article
- Proteomic response of Escherichia coli to a membrane lytic and iron chelating truncated Amaranthus tricolor defensin.BMC microbiology · 2021Article
- Multiple Classes of Antimicrobial Peptides inJournal of natural products · 2021Article
- Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies ofMicroorganisms · 2020Review
- Implementation of Microfluidics for Antimicrobial Susceptibility Assays: Issues and Optimization Requirements.Frontiers in cellular and infection microbiology · 2020Article
- PepSAVI-MS Reveals a Proline-rich Antimicrobial Peptide inJournal of natural products · 2019Article
- Article
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Authors and funding
18 authors.
Funding
Abstract
The recent increase in extensively drug-resistant bacterial pathogens and the associated increase of morbidity and mortality demonstrate the immediate need for new antibiotic backbones with novel mechanisms of action. Here, we report the development of the PepSAVI-MS pipeline for bioactive peptide discovery. This highly versatile platform employs mass spectrometry and statistics to identify bioactive peptide targets from complex biological samples. We validate the use of this platform through the successful identification of known bioactive peptides from a botanical species, Viola odorata. Using this pipeline, we have widened the known antimicrobial spectrum for V. odorata cyclotides, including antibacterial activity of cycloviolacin O2 against A. baumannii. We further demonstrate the broad applicability of the platform through the identification of novel anticancer activities for cycloviolacins by their cytotoxicity against ovarian, breast, and prostate cancer cell lines.
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Registered trials
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