Evidence map›Paper›PMID 27991730›Full record

ArticleEuropean journal of pain (London, England)2017

European Pain Federation position paper on appropriate opioid use in chronic pain management.

T O'Brien, L L Christrup, A M Drewes, M T Fallon, H G Kress, H J McQuay, G Mikus, B J Morlion, J Perez-Cajaraville, E Pogatzki-Zahn and 2 more

Registry-linked trialAbstract readConsensus Statement
In one paragraph

Article in European journal of pain (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03161795 (Addressing the Risks of Long-Term Opioid Therapy in Chronic Noncancer Pain), which is not on this map. Cited by 87 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03161795 completednot on this map

Addressing the Risks of Long-Term Opioid Therapy in Chronic Noncancer Pain: A National, Multicenter, and Observational Cross-sectional Study in South Korea

Typeobservational_patient_registrySponsorSeoul National UniversityRan2017 to 2018Enrolled258ConditionsChronic Noncancer Pain, Opioid-Related Disorders
3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
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  11. Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long-Term for Persistent Pain in Primary Care.Health expectations : an international journal of public participation in health care and health policy · 2025
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  12. Review
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

T O'BrienMarymount University Hospital & Hospice, Curraheen, Cork, Ireland.
L L ChristrupDepartment of Drug Design and Pharmacology, University of Copenhagen, Denmark.
A M DrewesMech-Sense, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Denmark.
M T FallonEdinburgh Cancer Research Centre, University of Edinburgh, UK.
H G KressDepartment of Special Anaesthesia and Pain Therapy, Medical University of Vienna/AKH, Austria.
H J McQuayBalliol College, Oxford, UK.
G MikusDepartment of Clinical Pharmacology and Pharmacoepidemiology, University Hospital, Heidelberg, Germany.
B J MorlionLeuven Centre for Algology & Pain Management, University Hospital Leuven, Belgium.
J Perez-CajaravillePain Functional Unit, University Hospital HM Madrid, Spain.
E Pogatzki-ZahnDepartment of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Müenster, Germany.
G VarrassiPaolo Procacci Foundation, Rome, Italy.
J C D WellsPain Matters Ltd, Liverpool, UK.

Funding

Marie Curie MCCC-RP-15-A18862
6 · The paper itself

Abstract

Poorly controlled pain is a global public health issue. The personal, familial and societal costs are immeasurable. Only a minority of European patients have access to a comprehensive specialist pain clinic. More commonly the responsibility for chronic pain management and initiating opioid therapy rests with the primary care physician and other non-specialist opioid prescribers. There is much confusing and conflicting information available to non-specialist prescribers regarding opioid therapy and a great deal of unjustified fear is generated. Opioid therapy should only be initiated by competent clinicians as part of a multi-faceted treatment programme in circumstances where more simple measures have failed. Throughout, all patients must be kept under close clinical surveillance. As with any other medical therapy, if the treatment fails to yield the desired results and/or the patient is additionally burdened by an unacceptable level of adverse effects, the overall management strategy must be reviewed and revised. No responsible clinician will wish to pursue a failed treatment strategy or persist with an ineffective and burdensome treatment. In a considered attempt to empower and inform non-specialist opioid prescribers, EFIC convened a European group of experts, drawn from a diverse range of basic science and relevant clinical disciplines, to prepare a position paper on appropriate opioid use in chronic pain. The expert panel reviewed the available literature and harnessed the experience of many years of clinical practice to produce these series of recommendations. Its success will be judged on the extent to which it contributes to an improved pain management experience for chronic pain patients across Europe. SIGNIFICANCE: This position paper provides expert recommendations for primary care physicians and other non- specialist healthcare professionals in Europe, particularly those who do not have ready access to specialists in pain medicine, on the safe and appropriate use of opioid medications as part of a multi-faceted approach to pain management, in properly selected and supervised patients.

Indexed as

Pain ManagementAnalgesics, OpioidAttitude of Health PersonnelChronic PainClinical ProtocolsEuropeHumansPatient SelectionPractice Patterns, Physicians'Analgesics, Opioid

Identifiers

PMID27991730
PMCPMC6680203

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.