ArticleJournal of the American Geriatrics Society2017
Weight Trajectory over 20 Years and Likelihood of Mild Cognitive Impairment or Dementia Among Older Women.
Article in Journal of the American Geriatrics Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020Pooled it
- Trial
- Long-term variability in physiological measures and risk of frailty: evidence from two cohort studies.The journal of nutrition, health & aging · 2026Article
- Socioeconomic disparities in physiological dysregulation: a longitudinal mediation analysis of cardiometabolic multimorbidity among middle-aged and elderly Chinese.BMC public health · 2025Observational
- Article
- Association of midlife body-weight variability and cycles with earlier dementia onset: a nationwide cohort study.Alzheimer's research & therapy · 2024Article
- Article
- Association Between Late-Life Weight Change and Dementia: A Population-based Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Long-term variability in physiological measures in relation to mortality and epigenetic aging: prospective studies in the USA and China.BMC medicine · 2023Article
- PROtein enriched MEDiterranean diet to combat undernutrition and promote healthy neuroCOGnitive ageing in older adults: The PROMED-COG consortium project.Nutrition bulletin · 2022Article
- Long-term Weight Change and its Temporal Relation to Later-life Dementia in the Health and Retirement Study.The Journal of clinical endocrinology and metabolism · 2022Article
- Longitudinal Body Weight Change, Visit-To-Visit Body Weight Fluctuation, and Cognitive Decline Among Older Adults.Journal of Alzheimer's disease : JAD · 2021Article
- Factors associated with unintentional weight loss among older adults in a geriatric outpatient clinic of university hospital.PloS one · 2021Article
- Do menopausal status and APOE4 genotype alter the long-term effects of intensive lifestyle intervention on cognitive function in women with type 2 diabetes mellitus?Neurobiology of aging · 2020Article
- Body Weight Variability Increases Dementia Risk Among Older Adults: A Nationwide Population-Based Cohort Study.Frontiers in endocrinology · 2020Article
- Obesity and Longer Term Risks of Dementia in 65-74 Year Olds.Age and ageing · 2019Article
- Variability in metabolic parameters and risk of dementia: a nationwide population-based study.Alzheimer's research & therapy · 2018Article
- Long-Term Weight Trajectory and Risk of Hip Fracture, Falls, Impaired Physical Function, and Death.Journal of the American Geriatrics Society · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectivesThe association between weight change and cognition is controversial. We examined the association between 20-year weight change and cognitive function in late life.
designCohort study.
settingStudy of Osteoporotic Fractures (SOF).
participantsOne thousand two hundred eighty-nine older, community-dwelling women (mean baseline age 68 (65-81) and 88 (82-102) at cognitive testing). MEASUREMENTS: Study of Osteoporotic Fractures participants had body weight measured repeatedly over 20 years (mean 8 weights). Adjudicated cognitive status was classified as normal (n = 775) or mild cognitive impairment (MCI)/dementia (n = 514) at Year 20. Logistic models were used to evaluate whether absolute weight change, rate of weight loss per year, presence of abrupt, unrecovered weight loss, and weight variability were associated with MCI or dementia.
resultsWomen with greater rate of weight loss over 20 years had increased chance of developing MCI or dementia. In age/education/clinic-adjusted "base" models, each 0.5 kg/yr decrease resulted in 30% increased odds of MCI/dementia (OR = 1.30 [95% CI: 1.14, 1.49]). After adjustment for age, education, clinic, depression, and walking speed, there was 17% (OR = 1.17 [95% CI: 1.02, 1.35]) increased odds of MCI/dementia for each 0.5 kg/yr decrease in weight. In base models, variability in weight was significant. Each 1% average deviation from each woman's predicted weight curve was associated with 11% increased odds of MCI/dementia (OR = 1.11 [95% CI: 1.04, 1.18]). The estimate was attenuated after full adjustment (OR = 1.06 [95% CI: 0.99, 1.14]). The presence of an abrupt weight decline was not associated with MCI/dementia.
conclusionsRate of weight loss over 20 years was associated with development of MCI or dementia in women surviving past 80 years, suggesting that nutritional status, social-environmental factors, and/or adipose tissue function and structure may affect cognitive function with aging.
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