ArticleScientific reports2016
An integrated multi-omics analysis of the NK603 Roundup-tolerant GM maize reveals metabolism disturbances caused by the transformation process.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 74 citations in OpenAlex.
- Non-targeted metabolite profiling reveals substantial equivalence of omega-3 enrichedGM crops & food · 2026Article
- Integrating Targeted Metabolomics and Targeted Proteomics to Study the Responses of Wheat Plants to Engineered Nanomaterials.ACS agricultural science & technology · 2024Article
- Impact of Intron and Retransformation on Transgene Expression in Leaf and Fruit Tissues of Field-Grown Pear Trees.International journal of molecular sciences · 2023Article
- Unravelling the Phytotoxic Effects of Glyphosate on Sensitive and ResistantPlants (Basel, Switzerland) · 2023Article
- Approach strategies and application of metabolomics to biotechnology in plants.Frontiers in plant science · 2023Review
- Proteomic Profile of Glyphosate-Resistant Soybean under Combined Herbicide and Drought Stress Conditions.Plants (Basel, Switzerland) · 2021Article
- The utility of metabolomics as a tool to inform maize biology.Plant communications · 2021Review
- LC-MS untargeted metabolomics assesses the delayed response of glufosinate treatment of transgenic glufosinate resistant (GR) buffalo grasses (Stenotaphrum secundatum L.).Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Evaluation on reprogramed biological processes in transgenic maize varieties using transcriptomics and metabolomics.Scientific reports · 2021Article
- Evaluation of the use of untargeted metabolomics in the safety assessment of genetically modified crops.Metabolomics : Official journal of the Metabolomic Society · 2020Review
- Utilization of GC-MS untargeted metabolomics to assess the delayed response of glufosinate treatment of transgenic herbicide resistant (HR) buffalo grasses (Stenotaphrum secundatum L.).Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Systematic Multi-Omics Integration (MOI) Approach in Plant Systems Biology.Frontiers in plant science · 2020Review
- RoundupToxics · 2019Article
- Recent developments in metabolomics-based research in understanding transgenic grass metabolism.Metabolomics : Official journal of the Metabolomic Society · 2019Review
- Article
- Comments on two recent publications on GM maize and Roundup.Scientific reports · 2018Article
- Reply to 'Comments on two recent publications on GM maize and Roundup'.Scientific reports · 2018Article
- Characterization of GMO or glyphosate effects on the composition of maize grain and maize-based diet for rat feeding.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Revisiting Risk Governance of GM Plants: The Need to Consider New and Emerging Gene-Editing Techniques.Frontiers in plant science · 2018Review
- Systematic miRNome profiling reveals differential microRNAs in transgenic maize metabolism.Environmental sciences Europe · 2018Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glyphosate tolerant genetically modified (GM) maize NK603 was assessed as 'substantially equivalent' to its isogenic counterpart by a nutrient composition analysis in order to be granted market approval. We have applied contemporary in depth molecular profiling methods of NK603 maize kernels (sprayed or unsprayed with Roundup) and the isogenic corn to reassess its substantial equivalence status. Proteome profiles of the maize kernels revealed alterations in the levels of enzymes of glycolysis and TCA cycle pathways, which were reflective of an imbalance in energy metabolism. Changes in proteins and metabolites of glutathione metabolism were indicative of increased oxidative stress. The most pronounced metabolome differences between NK603 and its isogenic counterpart consisted of an increase in polyamines including N-acetyl-cadaverine (2.9-fold), N-acetylputrescine (1.8-fold), putrescine (2.7-fold) and cadaverine (28-fold), which depending on context can be either protective or a cause of toxicity. Our molecular profiling results show that NK603 and its isogenic control are not substantially equivalent.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.