ArticleScientific reports2016
The Safety Limits Of An Extended Fast: Lessons from a Non-Model Organism.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Fieldwork on animals living in extreme conditions as a source of biomedical innovation.Science in One Health · 2025Review
- Diversifying the concept of model organisms in the age of -omics.Communications biology · 2023Review
- Fasting increases microbiome-based colonization resistance and reduces host inflammatory responses during an enteric bacterial infection.PLoS pathogens · 2021Article
- Transcriptional Changes Involved in Atrophying Muscles during Prolonged Fasting in Rats.International journal of molecular sciences · 2020Article
- Unravelling the health effects of fasting: a long road from obesity treatment to healthy life span increase and improved cognition.Annals of medicine · 2020Review
- Chronic Inflammation in the Context of Everyday Life: Dietary Changes as Mitigating Factors.International journal of environmental research and public health · 2020Review
- Safety, health improvement and well-being during a 4 to 21-day fasting period in an observational study including 1422 subjects.PloS one · 2019Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While safety of fasting therapy is debated in humans, extended fasting occurs routinely and safely in wild animals. To do so, food deprived animals like breeding penguins anticipate the critical limit of fasting by resuming feeding. To date, however, no molecular indices of the physiological state that links spontaneous refeeding behaviour with fasting limits had been identified. Blood proteomics and physiological data reveal here that fasting-induced body protein depletion is not unsafe "per se". Indeed, incubating penguins only abandon their chick/egg to refeed when this state is associated with metabolic defects in glucose homeostasis/fatty acid utilization, insulin production and action, and possible renal dysfunctions. Our data illustrate how the field investigation of "exotic" models can be a unique source of information, with possible biomedical interest.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.