ArticleScientific reports2016
Inertial Focusing of Microparticles in Curvilinear Microchannels.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Ridge-assisted micro positioning of cells in a channel.Science advances · 2026Article
- Ridge-assisted Micro Positioning of Cells and Particles in a Microchannel.bioRxiv : the preprint server for biology · 2025Article
- Micropump integrated white blood cell separation platform for detection of chronic granulomatous disease.Mikrochimica acta · 2024Article
- Enhancing particle focusing: a comparative experimental study of modified square wave and square wave microchannels in lift and Dean vortex regimes.Scientific reports · 2024Article
- Validation of an on-chip p16Scientific reports · 2023Article
- Establishment of a Perfusion Process with Antibody-Producing CHO Cells Using a 3D-Printed Microfluidic Spiral Separator with Web-Based Flow Control.Bioengineering (Basel, Switzerland) · 2023Article
- Sheathless inertial particle focusing methods within microfluidic devices: a review.Frontiers in bioengineering and biotechnology · 2023Review
- Biomedical Applications of Microfluidic Devices: A Review.Biosensors · 2022Review
- A Hybrid Spiral Microfluidic Platform Coupled with Surface Acoustic Waves for Circulating Tumor Cell Sorting and Separation: A Numerical Study.Biosensors · 2022Article
- Differential Sorting of Microparticles Using Spiral Microchannels with Elliptic Configurations.Micromachines · 2020Article
- Sheath-less high throughput inertial separation of small microparticles in spiral microchannels with trapezoidal cross-section.RSC advances · 2019Article
- Label-free microfluidic sorting of microparticles.APL bioengineering · 2019Review
- Inertial Focusing and Separation of Particles in Similar Curved Channels.Scientific reports · 2019Article
- New insights into the physics of inertial microfluidics in curved microchannels. I. Relaxing the fixed inflection point assumption.Biomicrofluidics · 2019Article
- Sheathless inertial cell focusing and sorting with serial reverse wavy channel structures.Microsystems & nanoengineering · 2018Article
- Electrokinetically driven continuous-flow enrichment of colloidal particles by Joule heating induced temperature gradient focusing in a convergent-divergent microfluidic structure.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A passive, continuous and size-dependent focusing technique enabled by "inertial microfluidics", which takes advantage of hydrodynamic forces, is implemented in this study to focus microparticles. The objective is to analyse the decoupling effects of inertial forces and Dean drag forces on microparticles of different sizes in curvilinear microchannels with inner radius of 800 μm and curvature angle of 280°, which have not been considered in the literature related to inertial microfluidics. This fundamental approach gives insight into the underlying physics of particle dynamics and offers continuous, high-throughput, label-free and parallelizable size-based particle separation. Our design allows the same footprint to be occupied as straight channels, which makes parallelization possible with optical detection integration. This feature is also useful for ultrahigh-throughput applications such as flow cytometers with the advantages of reduced cost and size. The focusing behaviour of 20, 15 and 10 μm fluorescent polystyrene microparticles was examined for different channel Reynolds numbers. Lateral and vertical particle migrations and the equilibrium positions of these particles were investigated in detail, which may lead to the design of novel microfluidic devices with high efficiency and high throughput for particle separation, rapid detection and diagnosis of circulating tumour cells with reduced cost.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.