Evidence map›Paper›PMID 27990727›Full record

ArticleAngewandte Chemie (International ed. in English)2017

Coupling Sensitive Nucleic Acid Amplification with Commercial Pregnancy Test Strips.

Yan Du, Arti Pothukuchy, Jimmy D Gollihar, Armin Nourani, Bingling Li, Andrew D Ellington

Open access · greenAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
9.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 159 citations in OpenAlex.

  1. Review
  2. An Integrated Approach to Improve the Assay Performance of Quantum Dot-Based Lateral Flow Immunoassays by Using Silver Deposition.Microchemical journal : devoted to the application of microtechniques in all branches of science · 2023
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  18. A stoichiometric and pseudo kinetic model of loop mediated isothermal amplification.Computational and structural biotechnology journal · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Yan DuInstitute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, Department of Chemistry, The University of Texas at Austin, Austin, TX, 78712, USA.
Arti PothukuchyInstitute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, Department of Chemistry, The University of Texas at Austin, Austin, TX, 78712, USA.
Jimmy D GolliharInstitute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, Department of Chemistry, The University of Texas at Austin, Austin, TX, 78712, USA.
Armin NouraniInstitute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, Department of Chemistry, The University of Texas at Austin, Austin, TX, 78712, USA.
Bingling LiState Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Jilin, P.R. China.
Andrew D EllingtonInstitute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, Department of Chemistry, The University of Texas at Austin, Austin, TX, 78712, USA.
The University of Texas at Austin · USChinese Academy of Sciences · CN

Funding

Center for Innovation in Point of Care Technologies for the Future of Cancer CareU54EB015403 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI KLAPPERICH, CATHERINE M. · 2012 to 2016
$8.9M
NIBIB NIH HHS U54 EB015403
6 · The paper itself

Abstract

The detection of nucleic acid biomarkers for point-of-care (POC) diagnostics is currently limited by technical complexity, cost, and time constraints. To overcome these shortcomings, we have combined loop-mediated isothermal amplification (LAMP), programmable toehold-mediated strand-exchange signal transduction, and standard pregnancy test strips. The incorporation of an engineered hCG-SNAP fusion reporter protein (human chorionic gonadotropin-O

Indexed as

Nucleic Acid Amplification TechniquesPregnancy TestsBiomarkersFemaleHumansNucleic AcidsPoint-of-Care SystemsPregnancyBiomarkersNucleic Acidshuman chorionic gonadotropinloop-mediated isothermal amplification (LAMP)nucleic acid amplificationpregnancy test stripsSNAP protein

Identifiers

PMID27990727
PMCPMC5240841
OpenAlexW2561894129

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.