Evidence map›Paper›PMID 27990611›Full record

ArticleInternational urology and nephrology2017

Coronary risk score for mineral bone disease in chronic non-diabetic hemodialysis patients: results from a prospective pilot study.

Cristiana David, Jordi Bover, Cornelia Voiculet, Ileana Peride, Lucian Cristian Petcu, Andrei Niculae, Adrian Covic, Ionel Alexandru Checherita

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Article in International urology and nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Cristiana DavidDepartment of Nephrology and Dialysis, "St. John" Emergency Clinical Hospital Bucharest, 37th Dionisie Lupu StreetSector 2, 020021, Bucharest, Romania.
Jordi BoverDepartment of Nephrology, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.
Cornelia VoiculetDepartment of Internal Medicine, "St. John" Emergency Clinical Hospital Bucharest, Bucharest, Romania.
Ileana PerideDepartment of Nephrology and Dialysis, "St. John" Emergency Clinical Hospital Bucharest, 37th Dionisie Lupu StreetSector 2, 020021, Bucharest, Romania.
Lucian Cristian PetcuDepartment of Biostatistics and Biophysics, Faculty of Dental Medicine, "Ovidius" University Constanta, Constanta, Romania.
Andrei NiculaeDepartment of Nephrology and Dialysis, "St. John" Emergency Clinical Hospital Bucharest, 37th Dionisie Lupu StreetSector 2, 020021, Bucharest, Romania. niculaeandrei@yahoo.com.
Adrian CovicDepartment of Nephrology, "Dr. C. I. Parhon" Clinical Hospital Iasi, Iasi, Romania.
Ionel Alexandru ChecheritaDepartment of Nephrology and Dialysis, "St. John" Emergency Clinical Hospital Bucharest, 37th Dionisie Lupu StreetSector 2, 020021, Bucharest, Romania.
Carol Davila University of Medicine and Pharmacy · ROClinical Emergency Hospital Bucharest · ROOvidius University · ROSpitalul Clinic Dr. C. I. Parhon · ROUniversitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChronic kidney disease-mineral bone disorder enhances coronary artery impairment (often occult and difficult to diagnose) in hemodialysis (HD) patients. The aim of the study was to correlate biochemical and imagistic parameters of MBD with the degree of documented coronary artery disease (CAD) in non-diabetic HD patients, in order to obtain a MBD-coronary risk score as a screening algorithm.

methodsA 3-year prospective study was conducted on 168 non-diabetic HD patients, evaluating MBD biochemical parameters along with pulse wave velocity (PWV) determination and valve/coronary calcification assessment; coronary angiography was performed in symptomatic patients. Correlations between noninvasive parameters and the degree of coronary obstruction were assessed using IBM SPSS Statistics 20 software, Chi-square test and the determination of odds ratio.

resultsSignificant differences in serum calcium (p < 0.001), phosphates (p = 0.03), bicarbonate (p < 0.001), albumin and iPTH (p = 0.002), percentage of deviations from PWV normal values (p = 0.004), average doses of phosphate binders and vitamin D and the number of vascular/valve calcifications were noted between the study group (angina, n = 17) and control group (asymptomatic, n = 151). After applying MBD-coronary risk score in control group, coronary angiography was performed in high-score patients.

conclusionA noninvasive screening algorithm for early diagnosis of CAD in asymptomatic HD patients with altered MBD parameters is necessary. Applying MBD-coronary risk score might be an important step in the prevention of major coronary episodes by extending the indication for further investigations, early diagnosis and treatment management.

Indexed as

AdultAgedAlkaline PhosphataseAngina, StableAngina, UnstableBicarbonatesBone Diseases, MetabolicCalciumCoronary AngiographyCoronary Artery DiseaseFemaleHumansKidney Failure, ChronicMaleMiddle AgedParathyroid HormoneAlkaline PhosphataseBicarbonatesCalciumParathyroid HormonePhosphatesSerum AlbuminChronic hemodialysisCoronary angiographyCoronary risk scoreMineral bone disorder

Identifiers

PMID27990611
OpenAlexW2564395839

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.