ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2017
A novel environmental exposure index and its interaction with familial susceptibility on oral cancer in non-smokers and non-drinkers: a case-control study.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Passive smoking and risk of head and neck cancer: a systematic review and meta-analysis.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2025Pooled it
- Chronic mechanical trauma/irritation and oral carcinoma: A systematic review showing low evidence to support an association.Oral diseases · 2022Pooled it
- Association of Oral Health Determinants With Oral Squamous Cell Carcinoma in Never-Smoking Adults.Head & neck · 2025Article
- A composite oral hygiene score and the risk of oral cancer and its subtypes: a large-scale propensity score-based study.Clinical oral investigations · 2022Article
- Molecular drivers of oral cavity squamous cell carcinoma in non-smoking and non-drinking patients: what do we know so far?Oncology reviews · 2022Article
- Combined effects of lung disease history, environmental exposures, and family history of lung cancer to susceptibility of lung cancer in Chinese non-smokers.Respiratory research · 2021Article
- Association Between Rare Earth Element Cerium and the Risk of Oral Cancer: A Case-Control Study in Southeast China.Frontiers in public health · 2021Article
- Variants in FAT1 and COL9A1 genes in male population with or without substance use to assess the risk factors for oral malignancy.PloS one · 2019Article
- Nomograms and risk scores for predicting the risk of oral cancer in different sexes: a large-scale case-control study.Journal of Cancer · 2018Article
- Dietary score and the risk of oral cancer: a case-control study in southeast China.Oncotarget · 2017Article
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10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to explore the collective effect of environmental factors and its interaction with familial susceptibility on oral cancer among non-smokers and non-drinkers (NSND). A hospital-based case-control study, including 319 oral cancer patients and 994 frequency-matched controls, was conducted in Fujian, China. We raised a weighed environmental exposure index according to nine significant environmental factors obtained from multivariable logistic regression model. And then, the index was classified into three categories according to the tertiles of controls (<1.34, 1.34-2.43, and >2.43). Multiplicative and additive interactions were evaluated between environmental exposure index and family cancer history. Our results showed that environmental exposure index was associated with an increased risk of oral cancer especially for those with family cancer history. Compared to subjects with low environmental exposure index and without family cancer history, those with high index and family cancer history showed the highest magnitude of OR in oral cancer risk (OR 10.40, 95% CI 5.46-19.80). Moreover, there was a multiplicative interaction between environmental exposure index and family cancer history for the risk of oral cancer (P < 0.001). This study puts forward a novel environmental exposure index, which enables a comprehensive evaluation on the overall effect of environmental risk factors on oral cancer among NSND and may interact with family cancer history. Further studies are warranted to explore the underlying mechanisms.
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