Evidence map›Paper›PMID 27990587›Full record

ArticleAIDS and behavior2017

Willingness to Use Pre-Exposure Prophylaxis (PrEP): An Empirical Test of the Information-Motivation-Behavioral Skills (IMB) Model among High-Risk Drug Users in Treatment.

Roman Shrestha, Frederick L Altice, Tania B Huedo-Medina, Pramila Karki, Michael Copenhaver

Registry-linked trialAbstract read
In one paragraph

Article in AIDS and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03282890 (Testing an Integrated Bio-Behavioral Primary HIV Prevention Intervention Among High-Risk People Who Use Drugs), which is not on this map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03282890 nacompletednot on this map

Testing an Integrated Bio-Behavioral Primary HIV Prevention Intervention Among High-Risk People Who Use Drugs

TypeinterventionalSponsorUniversity of ConnecticutRan2017 to 2023Enrolled237ConditionsRisk Behavior, HIV/AIDS, Medication Adherence, Substance AbuseArmsCHRP-BB
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Roman ShresthaDepartment of Community Medicine and Health Care, University of Connecticut Health Center, 263 Farmington Avenue, MC 6325, Farmington, CT, 06030-6325, USA. Roman.Shrestha@UConn.edu.ORCID http://orcid.org/0000-0003-4340-3101
Frederick L AlticeInstitute for Collaboration on Health, Intervention, and Policy, University of Connecticut, Storrs, CT, USA.
Tania B Huedo-MedinaInstitute for Collaboration on Health, Intervention, and Policy, University of Connecticut, Storrs, CT, USA.
Pramila KarkiInstitute for Collaboration on Health, Intervention, and Policy, University of Connecticut, Storrs, CT, USA.
Michael CopenhaverInstitute for Collaboration on Health, Intervention, and Policy, University of Connecticut, Storrs, CT, USA.
University of Connecticut · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Intervention of HIV, Drug Use and the Criminal Justice System in MalaysiaR01DA025943 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2008 to 2012
$2.7M
Enhancing Health Outcomes Among HIV+ Substance AbusersK24DA017072 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2003 to 2012
$1.5M
HIV Prevention and Adherence Among Priority Drug Using PopulationsK02DA033139 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI COPENHAVER, MICHAEL · 2013 to 2017
$697k
NCATS NIH HHS UL1 TR001863NIDA NIH HHS K02 DA033139NIDA NIH HHS K24 DA017072NIDA NIH HHS R01 DA025943
6 · The paper itself

Abstract

Evidence from recent pre-exposure prophylaxis (PrEP) trials has demonstrated its safety and efficacy in significantly reducing the risk of HIV acquisition for those who are at considerable risk of acquiring HIV infection. With a rapid increase in the amount of research on the efficacy of PrEP for HIV prevention, complementary research on the willingness to use PrEP has grown, especially among MSM, but limited research has been focused among people who use drugs (PWUD). As part of the formative process, we utilized the information-motivation-behavioral skills (IMB) model of health behavior change to characterize and guide intervention development for promoting willingness to use PrEP among high-risk PWUD. The analysis included 400 HIV-negative high-risk PWUD enrolled in a community-based methadone maintenance treatment who reported drug- and/or sex-related HIV risk behaviors in the past 6-months. Analyses revealed support for the IMB model as PrEP-related behavioral skills were found to mediate the influence of PrEP-related information and motivation on willingness to use PrEP. The results provide evidence as to the utility of the IMB model to increase willingness to use PrEP among high-risk PWUD. It therefore makes an important contribution to our understanding of the applicability of theoretically-grounded models of willingness to use PrEP among high-risk PWUD, who are one of the key risk populations who could benefit from the use of PrEP.

Indexed as

Behavior TherapyHealth EducationMotivationNarcoticsPre-Exposure ProphylaxisAdultCross-Sectional StudiesDrug UsersFemaleHIV InfectionsHumansMaleMethadoneMiddle AgedModels, PsychologicalOpiate Substitution TreatmentMethadoneNarcoticsHIVIMB modelPeople who use drugsPre-exposure prophylaxisStructural equation modelingSubstance use

Identifiers

PMID27990587
PMCPMC5380590
OpenAlexW2564198193

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.