ArticleAIDS and behavior2018
A Longitudinal Analysis of the Impact of Physical Activity on Neurocognitive Functioning Among HIV-Infected Adults.
Article in AIDS and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Facilitators and barriers to physical activity in middle-aged and older adult(s) HIV infected persons: a systematic review of qualitative studies.Frontiers in public health · 2026Pooled it
- Feasibility and Impact of a Yoga Intervention on Cognition, Physical Function, Physical Activity, and Affective Outcomes among People Living with HIV: A Randomized Controlled Pilot Trial.Journal of the International Association of Providers of AIDS CareTrial
- The interplay of comorbidity, disability, and physical activity among older adults living with HIV: insights from the CHANGE HIV study.BMC geriatrics · 2026Article
- Associated Factors of Cognitive Frailty in People Living with HIV Aged 50 and Older: A Cross-Sectional Study.Infectious diseases and therapy · 2025Article
- Design and rationale for a randomized clinical trial testing the efficacy of a lifestyle physical activity intervention for people with HIV and engaged in unhealthy drinking.Contemporary clinical trials · 2024Article
- Preventing Cognitive Decline in Older Latino Adults With HIV Through a Culturally Tailored Health Promotion Intervention: Protocol for a Single-Arm Pilot Trial.JMIR research protocols · 2024Article
- Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management.Nature reviews. Neurology · 2023Review
- The Association Between Objectively-Measured Physical Activity and Cognitive Functioning in Middle-Aged and Older People Living with HIV.AIDS and behavior · 2023Article
- Predictors of an Active Lifestyle in Middle-Aged and Older Adults with HIV in the United States Deep South.HIV/AIDS (Auckland, N.Z.) · 2023Article
- Preventing Neurocognitive Decline in Adults Aging with HIV: Implications for Practice and Research.Journal of Alzheimer's disease : JAD · 2023Review
- Late-life physical activity relates to brain tissue synaptic integrity markers in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Developments in Neuroprotection for HIV-Associated Neurocognitive Disorders (HAND).Current HIV/AIDS reports · 2022Review
- Aerobic Exercise in HIV-Associated Neurocognitive Disorders: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2022Article
- Construct Validity and Responsiveness of the Rapid Assessment of Physical Activity in Adults Living With HIV.Archives of rehabilitation research and clinical translation · 2021Article
- Action for better brain health among people living with HIV: protocol for a randomized controlled trial.BMC infectious diseases · 2021Article
- Neurocognitive impairment in Spanish-speaking Latinos living with HIV in the US: Application of the neuropsychological norms for the US-Mexico border region in Spanish (NP-NUMBRS).The Clinical neuropsychologist · 2021Article
- Determinants of Common Mental Disorders Among People Living with HIV/AIDS Attending ART Service in Southern Ethiopia.HIV/AIDS (Auckland, N.Z.) · 2021Article
- Factors related to functional exercise capacity amongst people with HIV in Durban, South Africa.Health SA = SA Gesondheid · 2021Article
- Physical Activity and Exercise for Older People Living with HIV: A Scoping Review.HIV/AIDS (Auckland, N.Z.) · 2021Article
- Behavioral and Physical Activity Interventions for HAND.Current topics in behavioral neurosciences · 2021Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Higher levels of physical activity (PA) have been linked to better neurocognitive functioning in many populations. The current study examines the longitudinal association between PA and neurocognitive functioning among HIV-infected and HIV-uninfected persons. Community-dwelling adults (N = 291) self-reported level of PA and completed a comprehensive neuropsychological battery at two to four study visits (Mean follow-up time = 2.6 years). Participants were divided into three PA groups: "No PA" (no PA at any visit), "consistent PA" (PA at ≥50% of visits), and "inconsistent PA" (PA < 50% of visits). A mixed effect model, adjusting for significant covariates showed that all PA groups had statistically significant, yet modest, neurocognitive decline over time; and, the consistent PA group began with, and maintained, significantly better neurocognitive function compared to the other two PA groups. This effect was evident among both HIV-uninfected and HIV-infected persons, despite the fact that HIV-infected persons showed lower baseline neurocognitive function. PA is a modifiable lifestyle behavior that may help to protect against neurocognitive impairment regardless of HIV status, however, given the proportion of HIV-infected individuals who evidence neurocognitive difficulties, a focus on increasing PA seems warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.