ArticleCellular and molecular life sciences : CMLS2017
Coordinated shift of olfactory amino acid responses and V2R expression to an amphibian water nose during metamorphosis.
Article in Cellular and molecular life sciences : CMLS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Making sense of vertebrate senses from a neural crest and cranial placode evo-devo perspective.Trends in neurosciences · 2025Review
- Type 2 vomeronasal receptor expression in the olfactory organ of African lungfish, Protopterus annectens.Cell and tissue research · 2024Article
- Ancient and Nonuniform Loss of Olfactory Receptor Expression Renders the Shark Nose a De Facto Vomeronasal Organ.Molecular biology and evolution · 2023Article
- Tadpoles and frogs have a different sense of taste.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Electrophysiological responses to conspecific odorants in Xenopus laevis show potential for chemical signaling.PloS one · 2022Article
- Distinct interhemispheric connectivity at the level of the olfactory bulb emerges during Xenopus laevis metamorphosis.Cell and tissue research · 2021Article
- An Ancient Adenosine Receptor Gains Olfactory Function in Bony Vertebrates.Genome biology and evolution · 2021Article
- Article
- Neural pathways of olfactory kin imprinting and kin recognition in zebrafish.Cell and tissue research · 2021Review
- Olfactory subsystems in the peripheral olfactory organ of anuran amphibians.Cell and tissue research · 2021Review
- Coding of pheromones by vomeronasal receptors.Cell and tissue research · 2021Review
- Olfaction across the water-air interface in anuran amphibians.Cell and tissue research · 2021Review
- Conservation of Glomerular Organization in the Main Olfactory Bulb of Anuran Larvae.Frontiers in neuroanatomy · 2020Article
- Loss of olfaction in sea snakes provides new perspectives on the aquatic adaptation of amniotes.Proceedings. Biological sciences · 2019Article
- Excreted Steroids in Vertebrate Social Communication.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Review
- Functional Reintegration of Sensory Neurons and Transitional Dendritic Reduction of Mitral/Tufted Cells during Injury-Induced Recovery of the LarvalFrontiers in cellular neuroscience · 2017Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
All olfactory receptors identified in teleost fish are expressed in a single sensory surface, whereas mammalian olfactory receptor gene families segregate into different olfactory organs, chief among them the main olfactory epithelium expressing ORs and TAARs, and the vomeronasal organ expressing V1Rs and V2Rs. A transitional stage is embodied by amphibians, with their vomeronasal organ expressing more 'modern', later diverging V2Rs, whereas more 'ancient', earlier diverging V2Rs are expressed in the main olfactory epithelium. During metamorphosis, the main olfactory epithelium of Xenopus tadpoles transforms into an air-filled cavity (principal cavity, air nose), whereas a newly formed cavity (middle cavity) takes over the function of a water nose. We report here that larval expression of ancient V2Rs is gradually lost from the main olfactory epithelium as it transforms into the air nose. Concomitantly, ancient v2r gene expression begins to appear in the basal layers of the newly forming water nose. We observe the same transition for responses to amino acid odorants, consistent with the hypothesis that amino acid responses may be mediated by V2R receptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.