Evidence map›Paper›PMID 27990496›Full record

ArticleKidney international reports2016

Lupus-like Immune Complex-mediated Glomerulonephritis in Patients with Hepatitis C Virus Infection Treated with Oral, Interferon-free, Direct-acting Antiviral Therapy.

Meghan E Sise, Jessica Wisocky, Ivy A Rosales, Donald Chute, Jacinta A Holmes, Kristin M Corapi, Jodie L Babitt, Jessica S Tangren, Nikroo Hashemi, Andrew L Lundquist and 8 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Kidney international reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 29 citations in OpenAlex.

  1. Renal Manifestations of Chronic Hepatitis C: A Review.Journal of clinical medicine · 2024
    Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Immune gene expression in kidney biopsies of lupus nephritis patients at diagnosis and at renal flare.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2019
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Meghan E SiseDivision of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA.
Jessica WisockyGastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA.
Ivy A RosalesDepartment of Pathology, Massachusetts General Hospital, Boston, MA.
Donald ChuteGastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA.
Jacinta A HolmesGastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA.
Kristin M CorapiDivision of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA.
Jodie L BabittDivision of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA.
Jessica S TangrenDivision of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA.
Nikroo HashemiDepartment of Gastroenterology and Hepatology, Brigham and Women's Hospital, Boston, MA.
Andrew L LundquistDivision of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA.
Winfred W WilliamsDivision of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA.
David B MountRenal Unit, Brigham and Women's Hospital, Boston, MA.
Karin L AnderssonGastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA.
Helmut G RennkeDepartment of Pathology, Brigham and Women's Hospital, Boston, MA.
R Neal SmithDepartment of Pathology, Massachusetts General Hospital, Boston, MA.
Robert ColvinDepartment of Pathology, Massachusetts General Hospital, Boston, MA.
Ravi I ThadhaniDivision of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA.
Raymond T ChungGastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA.
Massachusetts General Hospital · USBrigham and Women's Hospital · US

Funding

Virology CoreU19AI082630 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG, GEORG Michael LAUER · 2009 to 2026
$48.1M
TRAINING IN CELL STRUCTURE AND FUNCTION IN NEPHROLOGYT32DK007540 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS, SOBERMAN, ROY · 1986 to 2021
$7.2M
Patient-Oriented Research on Hepatitis in Special PopulationsK24DK078772 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHUNG, RAYMOND T · 2007 to 2016
$1.6M
Patient Oriented Studies of Vitamin D in Chronic Kidney DiseaseK24DK094872 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI THADHANI, RAVI · 2012 to 2016
$546k
NIAID NIH HHS U19 AI082630NIDDK NIH HHS K24 DK078772NIDDK NIH HHS K24 DK094872NIDDK NIH HHS T32 DK007540
6 · The paper itself

Abstract

Novel, all-oral interferon-free direct-acting antiviral agents have revolutionized the management of hepatitis C virus (HCV) infection by producing exceptional cure rates with minimal adverse events. While provocation or exacerbation of autoimmunity has been reported in HCV-infected patients receiving interferon, this phenomenon has not been reported in patients receiving interferon-free HCV therapy. We report the occurrence of three cases of lupus-like immune complex-mediated glomerulonephritis occurring shortly after exposure to sofosbuvir-based direct-acting antiviral therapies. In all three cases, renal function quickly improved with immunosuppression. However, two of the three patients developed infectious complications of immunosuppression and died. This is the first report of a lupus-like immune complex mediated glomerulonephritis occurring in the context of HCV eradication with all-oral direct-acting antiviral therapies.

Identifiers

PMID27990496
PMCPMC5155703
OpenAlexW2467986200

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.