Evidence map›Paper›PMID 27990492›Full record

ArticleJSM Alzheimer's disease and related dementia2016

The Orphan C2orf40 Gene is a Neuroimmune Factor in Alzheimer's Disease.

Sonia Podvin, Miles C Miller, Ryan Rossi, Jasmine Chukwueke, John E Donahue, Conrad E Johanson, Andrew Baird, Edward G Stopa

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in JSM Alzheimer's disease and related dementia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sonia PodvinDepartment of Surgery, University of California San Diego School of Medicine, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, USA.
Miles C MillerDepartment of Pathology, Rhode Island Hospital, USA; Department of Neurosurgery, Warren Alpert Medical School of Brown University, USA.
Ryan RossiDepartment of Pathology, Rhode Island Hospital, USA.
Jasmine ChukwuekeDepartment of Pathology, Rhode Island Hospital, USA.
John E DonahueDepartment of Pathology, Rhode Island Hospital, USA.
Conrad E JohansonDepartment of Neurosurgery, Warren Alpert Medical School of Brown University, USA.
Andrew BairdDepartment of Surgery, University of California San Diego School of Medicine, USA.
Edward G StopaDepartment of Pathology, Rhode Island Hospital, USA; Department of Neurosurgery, Warren Alpert Medical School of Brown University, USA.
Brown University · USUniversity of California, San Diego · US

Funding

DISCOVERY OF NEW TREATMENTS FOR INTRAVENOUS DRUG ABUSER01DA007315 · NIDA · UNIVERSITY OF BRISTOL · PI HUSBANDS, STEPHEN M, TRAYNOR, JOHN R. · 1991 to 2019
$4.8M
A Combinatorial Approach to Wound Healing for Protein, Gene and Cell TherapeuticsP20GM078421 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAIRD, ANDREW · 2006 to 2009
$3.4M
TRAINING IN NEUROSCIENCE RELATED TO DRUG ABUSET32DA007315 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HOOK, VIVIAN Y. H · 2000 to 2013
$2.7M
Targeting the choroid plexus for drug translocation into CSFR21EY018479 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAIRD, ANDREW · 2007 to 2010
$606k
NEI NIH HHS R21 EY018479NIDA NIH HHS R01 DA007315NIDA NIH HHS T32 DA007315NIGMS NIH HHS P20 GM078421
6 · The paper itself

Abstract

Expression of the orphan C2orf40 gene is associated with the aggregation of the neurofibrillary tangle-protein tau in transgenic mice, tumor suppression, the induction of senescence in CNS, and the activation of microglia and peripheral mononuclear leukocytes. This gene also encodes several secreted pro- and anti-inflammatory neuropeptide-like cytokines, suggesting they might be implicated in the inflammatory component(s) of Alzheimer's disease (AD). Accordingly, we evaluated human AD and control brains for expression changes by RT-qPCR, Western blot, and histological changes by immunolabeling. RT-qPCR demonstrated increased cortical gene expression in AD. The molecular form of Ecrg4 detected in cortex was 8-10 kDa, which was shown previously to interact with the innate immunity receptor complex. Immunocytochemical studies showed intensely stained microglia and intravascular blood-borne monocytes within cerebral cortical white matter of AD patients. Staining was diminished within cortical neurons, except for prominent staining in neurofibrillary tangles. Choroid plexuses showed a decreasing trend. These findings support our hypothesis that c2orf40 participates in the neuroimmune response in AD.

Indexed as

Alzheimer’s diseaseEcrg4Neurofibrillary tangleNeuroimmune mechanismsWhite matter

Identifiers

PMID27990492
PMCPMC5157699
OpenAlexW2592393969

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.