ArticleNeurophotonics2016
Action potential block in neurons by infrared light.
Article in Neurophotonics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- FLIM quantification of temperature-dependent enzyme-NADH binding dynamics.Biomedical optics express · 2026Article
- Fast autofluorescence imaging to evaluate dynamic changes in cell metabolism.Journal of biomedical optics · 2024Article
- Two-photon imaging of excitatory and inhibitory neural response to infrared neural stimulation.Neurophotonics · 2024Article
- Selective Infrared Neural Inhibition Can Be Reproduced by Resistive Heating.Neuromodulation : journal of the International Neuromodulation Society · 2023Article
- Neuronal maturation-dependent nano-neuro interaction and modulation.Nanoscale horizons · 2023Article
- Single celliScience · 2023Article
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
- Histological and electrophysiological evidence on the safe operation of a sharp-tip multimodal optrode during infrared neuromodulation of the rat cortex.Scientific reports · 2022Article
- Advantages, Pitfalls, and Developments of All Optical Interrogation Strategies of MicrocircuitsFrontiers in neuroscience · 2022Review
- Multi-modal nonlinear optical and thermal imaging platform for label-free characterization of biological tissue.Scientific reports · 2021Article
- Optimizing thermal block length during infrared neural inhibition to minimize temperature thresholds.Journal of neural engineering · 2021Article
- Isotonic ion replacement can lower the threshold for selective infrared neural inhibition.Neurophotonics · 2021Article
- Spike frequency-dependent inhibition and excitation of neural activity by high-frequency ultrasound.The Journal of general physiology · 2020Article
- Infrared inhibition impacts on locally initiated and propagating action potentials and the downstream synaptic transmission.Neurophotonics · 2020Article
- Infrared neural stimulation and inhibition using an implantable silicon photonic microdevice.Microsystems & nanoengineering · 2020Article
- Infrared inhibition and waveform modulation of action potentials in the crayfish motor axon.Biomedical optics express · 2019Article
- Voltage-gated potassium channels are critical for infrared inhibition of action potentials: an experimental study.Neurophotonics · 2019Article
- Inhibitory effect of 980-nm laser on neural activity of the rat's cochlear nucleus.Neurophotonics · 2019Article
- Eye Movements Evoked by Pulsed Infrared Radiation of the Rat Vestibular System.Annals of biomedical engineering · 2018Article
- Pulsed infrared releases CaJournal of neurophysiology · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Short infrared laser pulses (SILP) have many physiological effects on cells, including the ability to stimulate action potentials (APs) in neurons. Here, we show that SILPs can also reversibly block APs. Reversible AP block in hippocampal neurons was observed following SILP (0.26 to [Formula: see text]; 1.37 to 5.01 ms; 1869 nm) with the block persisting for more than 1 s with exposures greater than [Formula: see text]. AP block was sustained for 30 s with SILPs pulsed at 1 to 7 Hz. Full recovery of neuronal activity was observed 5 to 30 s post SILP exposure. These results indicate that SILP can be used for noncontact, reversible AP block. Due to the high spatial precision and noncontact manner of infrared light delivery, AP block by SILP (infrared neural inhibition) has the potential to transform medical care for sustained pain inhibition and suppression of unwanted nerve activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.