Evidence map›Paper›PMID 27990446›Full record

ArticleMolecular therapy. Methods & clinical development2016

The superior regenerative potential of muscle-derived stem cells for articular cartilage repair is attributed to high cell survival and chondrogenic potential.

Hongshuai Li, Aiping Lu, Ying Tang, Sarah Beckman, Naoki Nakayama, Minakshi Poddar, MaCalus V Hogan, Johnny Huard

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Osteoarthritis: pathogenic signaling pathways and therapeutic targets.Signal transduction and targeted therapy · 2023
    Review
  8. Review
  9. Article
  10. Hypoxia-inducible factor 1α (HIF-1α) is a major determinant in the enhanced function of muscle-derived progenitors from MRL/MpJ mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  11. Cell therapy to improve regeneration of skeletal muscle injuries.Journal of cachexia, sarcopenia and muscle · 2019
    Review
  12. Gene therapy for chondral and osteochondral regeneration: is the future now?Cellular and molecular life sciences : CMLS · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Hongshuai LiDepartment of Orthopedic Surgery, Stem Cell Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Orthopedic Surgery, Musculoskeletal Growth & Regeneration Laboratory, University of Pittsburgh, Pennsylvania, USA.
Aiping LuDepartment of Orthopedic Surgery, Stem Cell Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Orthopedic Surgery, University of Texas Health Science Center at Houston, Houston, Texas, USA; Steadman Philippon Research Institute, Vail, Colorado, USA; Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston Medical School, Houston, Texas, USA.
Ying TangDepartment of Orthopedic Surgery, Stem Cell Research Center, University of Pittsburgh , Pittsburgh, Pennsylvania, USA.
Sarah BeckmanDepartment of Orthopedic Surgery, Stem Cell Research Center, University of Pittsburgh , Pittsburgh, Pennsylvania, USA.
Naoki NakayamaDepartment of Orthopedic Surgery, University of Texas Health Science Center at Houston, Houston, Texas, USA; Steadman Philippon Research Institute, Vail, Colorado, USA; Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston Medical School, Houston, Texas, USA.
Minakshi PoddarDepartment of Orthopedic Surgery, Stem Cell Research Center, University of Pittsburgh , Pittsburgh, Pennsylvania, USA.
MaCalus V HoganDepartment of Orthopedic Surgery, Stem Cell Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Orthopedic Surgery, Musculoskeletal Growth & Regeneration Laboratory, University of Pittsburgh, Pennsylvania, USA.
Johnny HuardDepartment of Orthopedic Surgery, Stem Cell Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Orthopedic Surgery, University of Texas Health Science Center at Houston, Houston, Texas, USA; Steadman Philippon Research Institute, Vail, Colorado, USA; Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston Medical School, Houston, Texas, USA.
University of Pittsburgh · USBrown Foundation · USSteadman Philippon Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three populations of muscle-derived cells (PP1, PP3, and PP6) were isolated from mouse skeletal muscle using modified preplate technique and retrovirally transduced with BMP4/GFP.

Identifiers

PMID27990446
PMCPMC5129874
OpenAlexW2559085087

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.