ArticleJournal of biosciences and medicines2016
Voriconazole-Induced Periostitis & Enthesopathy in Solid Organ Transplant Patients: Case Reports.
Article in Journal of biosciences and medicines, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Voriconazole-induced periostitis in a child with finger pain and nodules: case report and literature review.BMC musculoskeletal disorders · 2025Review
- Voriconazole-associated periostitis: Pathophysiology, risk factors, clinical manifestations, diagnosis, and management.World journal of transplantation · 2021Review
- Tolerability profile of the current antifungal armoury.The Journal of antimicrobial chemotherapy · 2018Review
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
backgroundVoriconazole is frequently used to treat fungal infections in solid organ transplant patients. Recently, there have been reports suggesting that prolonged voriconazole therapy may lead to periostitis.
aimHere we present two cases of voriconazole-induced periostitis in solid organ transplant patients. CASE PRESENTATION: Voriconazole was given to two transplant patients-one with a liver transplant and the second with a heart transplant, to treat their fungal infections. Both developed voriconazole-induced toxicity. While undergoing voriconazole therapy, they had incapacitating bone pain. The liver transplant patient had to be taken off voriconazole, and the heart transplant patient succumbed to non-voriconazole related causes.
conclusionsVoriconazole therapy in two solid organ transplant patients resulted in periostitis. We provide potential etiologies underlying voriconazole-induced periostitis, including fluoride toxicity, abnormalities in the pulmonary vascular bed leading to the production of downstream inflammatory mediators, and abnormal pharmacokinetics of hepatic drug metabolism. In addition to monitoring blood voriconazole trough levels, we suggest careful assessment for musculoskeletal pain in patients undergoing voriconazole treatment for two months or more, particularly if their daily dosages of voriconazole exceed 500 mg per day. Appropriate workup should include measurement of alkaline phosphatase, voriconazole trough and fluoride levels as well as a bone scan. Overall, early recognition of voriconazole-induced musculoskeletal toxicity is important for better morbidity outcomes.
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