ArticleInternational journal of ophthalmology2016
Effect of endothelial progenitor cells derived from human umbilical cord blood on oxygen-induced retinopathy in mice by intravitreal transplantation.
Article in International journal of ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Effects of fresh bone marrow mononuclear cell therapy in rat model of retinopathy of prematurity.Regenerative therapy · 2023Article
- Evans blue staining to detect deep blood vessels in peripheral retina for observing retinal pathology in early-stage diabetic rats.International journal of ophthalmology · 2021Article
- Differential MicroRNA Expression Pattern in Endothelial Progenitor Cells During Diabetic Retinopathy.Frontiers in cell and developmental biology · 2021Article
- Umbilical Cord Blood and Serum for the Treatment of Ocular Diseases: A Comprehensive Review.Ophthalmology and therapy · 2020Review
- Toward the Clinical Application of Therapeutic Angiogenesis Against Pediatric Ischemic Retinopathy.Journal of lipid and atherosclerosis · 2020Review
- Endothelial colony-forming cell therapy for heart morphological changes after neonatal high oxygen exposure in rats, a model of complications of prematurity.Physiological reports · 2018Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effect of endothelial progenitor cells (EPCs) labeled by carboxy fluorescein diacetate succinimidyl ester (CFSE) on murine oxygen-induced retinopathy (OIR) by intravitreal transplantation.
methodsAfter isolated from human umbilical cord blood mononuclear cells, EPCs were cultivated and then labeled with CFSE
resultsThe retinas from EPCs group with less non-perfusion area and fewer peripheral tufts were observed at P19, comparing with that from PBS or OIR group. The retinopathy in EPCs group receded earlier with less non-ganglion cells and neovascular nuclei, together with relatively regular distribution. The counts of the neovascular nuclei at P19 were reduced by 44% or 45%, compared with those of OIR group or PBS group respectively. Three days after EPCs injection, a large number of EPCs appeared in the vitreous cavity and adhered to the retinal surface. While at one week, the cells gathered between the internal plexiform layer and the inner limiting membrane, and some EPCs appeared in retinal vessels.
conclusionEPCs transplantation can participate in the reparative procedure of the neovascularization in OIR.
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Registered trials
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