Evidence map›Paper›PMID 27990358›Full record

ArticleInternational journal of ophthalmology2016

Neuropathy optic glaucomatosa induced by systemic hypertension through activation endothelin-1 signaling pathway in central retinal artery in rats.

Seskoati Prayitnaningsih, Hidayat Sujuti, Maksum Effendi, Aulia Abdullah, Nanda Wahyu Anandita, Febriani Yohana, Nur Permatasari, Mohamad Aris Widodo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Seskoati PrayitnaningsihDepartment of Ophthalmology, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia.
Hidayat SujutiDepartment of Ophthalmology, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia.
Maksum EffendiDepartment of Ophthalmology, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia.
Aulia AbdullahDepartment of Ophthalmology, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia.
Nanda Wahyu AnanditaDepartment of Ophthalmology, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia.
Febriani YohanaDepartment of Ophthalmology, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia.
Nur PermatasariPharmacology Laboratory, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia.
Mohamad Aris WidodoPharmacology Laboratory, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia.
University of Brawijaya · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate effect of hypertension on retinal ganglion cell (RGC) apoptosis, intraocular pressure (IOP), and the activation of endothelin-1 (ET-1) signaling pathway in central retinal artery (CRA) in rats.

methodsThe experimental study was performed on 20 male Sprague Dawley rats that were divided into control group, and hypertension groups. The hypertension was induced by subcutaneous deoxycorticoacetate (DOCA) 10 mg/kg twice a week and administered 0.9% NaCl solution daily for 2, 6, and 10wk. Blood pressure (BP) was measured using animal BP analyzer. IOP was measured by handheld tonometry. Retinal tissue preparations by paraffin blocks were made after enucleation. The expression of ET-1, eNOS, ET-1 receptor A (ETR

resultsBP significantly increased in all of the hypertension groups compared to control (

conclusionHypertension effects to activation of ET-1 signaling pathway significantly in CRA, elevation of IOP, and RGC apoptosis. The highest value was achieved at 2wk, which is the development phase of hypertension.

Indexed as

central retinal arteryendothelin-1 signaling pathwayhypertensionrats

Identifiers

PMID27990358
PMCPMC5145083
OpenAlexW2563816260

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.