ArticleChemical science2016
Asymmetric addition of α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid.
Article in Chemical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 70 citations in OpenAlex.
- Ketone α-alkylation at the more-hindered site.Nature communications · 2023Article
- Transferrable selectivity profiles enable prediction in synergistic catalyst space.Chemical science · 2023Article
- Synergistic Peptide and Gold Catalysis: Enantioselective Addition of Branched Aldehydes to Allenamides.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Asymmetric construction of acyclic quaternary stereocenters via direct enantioselective additions of α-alkynyl ketones to allenamides.Nature communications · 2021Article
- Recent progress in transition-metal-free functionalization of allenamides.RSC advances · 2020Review
- A complementary approach to conjugatedBeilstein journal of organic chemistry · 2020Article
- Enantioselective Functionalization of Enamides at the β-Carbon Center with Indoles.Angewandte Chemie (International ed. in English) · 2018Article
- Direct Asymmetric Alkylation of Ketones: Still Unconquered.Angewandte Chemie (International ed. in English) · 2017Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
We describe the asymmetric addition of unactivated α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid, generating an all-carbon quaternary stereocenter with broad substrate scope and high enantioselectivity. The products are easily transformed into their corresponding 1,5- and 1,4-ketoaldehyde derivatives, which are both important building blocks in organic synthesis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.