ArticleThe open neurology journal2016
Functional and Genomic Features of Human Genes Mutated in Neuropsychiatric Disorders.
Article in The open neurology journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- Functional Genomics of Epileptogenesis in Animal Models and Humans.Cellular and molecular neurobiology · 2021Article
- Integrative In Silico Analysis of Genome-Wide DNA Methylation Profiles in Schizophrenia.Journal of molecular neuroscience : MN · 2020Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundIn recent years, a large number of studies around the world have led to the identification of causal genes for hereditary types of common and rare neurological and psychiatric disorders.
objectiveTo explore the functional and genomic features of known human genes mutated in neuropsychiatric disorders.
methodsA systematic search was used to develop a comprehensive catalog of genes mutated in neuropsychiatric disorders (NPD). Functional enrichment and protein-protein interaction analyses were carried out. A false discovery rate approach was used for correction for multiple testing.
resultsWe found several functional categories that are enriched among NPD genes, such as gene ontologies, protein domains, tissue expression, signaling pathways and regulation by brain-expressed miRNAs and transcription factors. Sixty six of those NPD genes are known to be druggable. Several topographic parameters of protein-protein interaction networks and the degree of conservation between orthologous genes were identified as significant among NPD genes.
conclusionThese results represent one of the first analyses of enrichment of functional categories of genes known to harbor mutations for NPD. These findings could be useful for a future creation of computational tools for prioritization of novel candidate genes for NPD.
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