Evidence map›Paper›PMID 27990172›Full record

ReviewNutrition & metabolism2016

Nutritional modulation of endogenous glucagon-like peptide-1 secretion: a review.

Alexandra M Bodnaruc, Denis Prud'homme, Rosanne Blanchet, Isabelle Giroux

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrition & metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 124 citations in OpenAlex.

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  4. Effects of physical form ofThe British journal of nutrition · 2024
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  12. The probioticGut microbes
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alexandra M BodnarucSchool of Human Kinetics, Faculty of Health Sciences, University of Ottawa, 35, University Private, Room 050F, K1N 6N5 Ottawa, ON Canada ; Institut de Recherche de l'Hôpital Montfort, Institut du savoir, 745 Montreal Road, Room 202, K1K 0T2 Ottawa, ON Canada ; School of Nutrition Sciences, Faculty of Health Sciences, University of Ottawa, 35 University Private, Room 050F, K1N 6N5 Ottawa, ON Canada.
Denis Prud'hommeSchool of Human Kinetics, Faculty of Health Sciences, University of Ottawa, 35, University Private, Room 050F, K1N 6N5 Ottawa, ON Canada ; Institut de Recherche de l'Hôpital Montfort, Institut du savoir, 745 Montreal Road, Room 202, K1K 0T2 Ottawa, ON Canada.
Rosanne BlanchetSchool of Nutrition Sciences, Faculty of Health Sciences, University of Ottawa, 35 University Private, Room 050F, K1N 6N5 Ottawa, ON Canada.
Isabelle GirouxInstitut de Recherche de l'Hôpital Montfort, Institut du savoir, 745 Montreal Road, Room 202, K1K 0T2 Ottawa, ON Canada ; School of Nutrition Sciences, Faculty of Health Sciences, University of Ottawa, 25 University Private, Room 116, K1N 6N5 Ottawa, ON Canada.
University of Ottawa · CAMontfort Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe positive influences of glucagon-like peptide-1 (GLP-1) on blood glucose homeostasis, appetite sensations, and food intake provide a strong rationale for its therapeutic potential in the nutritional management of obesity and type 2 diabetes.

aimTo summarize GLP-1 physiology and the nutritional modulation of its secretion in the context of obesity and type 2 diabetes management.

findingsGLP-1 is mainly synthesized and secreted by enteroendocrine L-cells of the gastrointestinal tract. Its secretion is partly mediated by the direct nutrient sensing by G-protein coupled receptors which specifically bind to monosaccharides, peptides and amino-acids, monounsaturated and polyunsaturated fatty acids as well as to short chain fatty acids. Foods rich in these nutrients, such as high-fiber grain products, nuts, avocados and eggs also seem to influence GLP-1 secretion and may thus promote associated beneficial outcomes in healthy individuals as well as individuals with type 2 diabetes or with other metabolic disturbances.

conclusionThe stimulation of endogenous GLP-1 secretion by manipulating the composition of the diet may be a relevant strategy for obesity and type 2 diabetes management. A better understanding of the dose-dependent effects as well as the synergistic effects of nutrients and whole foods is needed in order to develop recommendations to appropriately modify the diet to enhance GLP-1 beneficial effects.

Indexed as

Appetite regulationBlood glucoseDietEnteroendocrine L-cellsG-protein coupled receptors

Identifiers

PMID27990172
PMCPMC5148911
OpenAlexW2559840873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.