Evidence map›Paper›PMID 27990155›Full record

ArticleAudiology and neurotology. Extra

Dietary supplement comprised of β-carotene, vitamin C, vitamin E, and magnesium: failure to prevent music-induced temporary threshold shift.

C G Le Prell, A Fulbright, C Spankovich, S K Griffiths, E Lobarinas, K C M Campbell, P J Antonelli, G E Green, K Guire, J M Miller

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Audiology and neurotology. Extra. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00808470 (Micronutrient Intervention to Reduce Noise-Induced Hearing Loss), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00808470 phase2completednot on this map

Micronutrient Intervention to Reduce Noise-Induced Hearing Loss: Prevention of Temporary Threshold Changes Induced by Use of a Digital Music Player

TypeinterventionalSponsorUniversity of MichiganRan2008 to 2013Enrolled72ConditionsNoise-Induced Hearing LossArmsbeta-carotene, vitamins C and E, magnesium, Placebo
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Octave band noise exposure: Laboratory models and otoprotection efforts.The Journal of the Acoustical Society of America · 2019
    Pooled it
  2. Pooled it
  3. Development and Validation of an Efficient and Safe Loud Music Exposure Paradigm.Journal of speech, language, and hearing research : JSLHR · 2024
    Article
  4. Article
  5. Article
  6. Noise-Induced Hearing Loss.Journal of clinical medicine · 2023
    Review
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  8. Review
  9. Article
  10. Review
  11. Review
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  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

C G Le PrellSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, Tex.
A FulbrightDepartment of Speech, Language, and Hearing Sciences, University of Florida, Gainesville, Fla.
C SpankovichDepartment of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, Miss.
S K GriffithsDepartment of Speech, Language, and Hearing Sciences, University of Florida, Gainesville, Fla.
E LobarinasSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, Tex.
K C M CampbellDepartment of Surgery, Southern Illinois University School of Medicine, Springfield, Ill.
P J AntonelliDepartment of Otolaryngology, University of Florida, Gainesville, Fla.
G E GreenDepartment of Otolaryngology, University of Michigan, Ann Arbor, Mich.
K GuireDepartment of Biostatistics, University of Michigan, Ann Arbor, Mich.
J M MillerDepartment of Otolaryngology, University of Michigan, Ann Arbor, Mich.

Funding

Micronutrient intervention to reduce noise-induced hearing lossU01DC008423 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MILLER, JOSEF MAYER · 2008 to 2011
$3.0M
NIDCD NIH HHS U01 DC008423
6 · The paper itself

Abstract

This study examined potential prevention of music-induced temporary threshold shift (TTS) in normal-hearing participants. A dietary supplement composed of β-carotene, vitamins C and E, and magnesium was assessed using a randomized, placebo-controlled, double-blind study design. Dosing began 3 days prior to the music exposure with the final dose consumed approximately 30-min pre-exposure. There were no group differences in post-exposure TTS or music-induced decreases in distortion product otoacoustic emission (DPOAE) amplitude. Transient tinnitus was more likely to be reported by the treatment group, but there were no group differences in perceived loudness or bothersomeness. All subjects were monitored until auditory function returned to pre-exposure levels. Taken together, this supplement had no effect on noise-induced changes in hearing. Recommendations for future clinical trials are discussed.

Indexed as

digital audio playerdistortion product otoacoustic emissionmagnesiumtemporary threshold shifttinnitusvitamin Cvitamin Eβ-carotene

Identifiers

PMID27990155
PMCPMC5156316

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.