Evidence map›Paper›PMID 27990145›Full record

ArticleFrontiers in immunology2016

Oxidative Burst-Dependent NETosis Is Implicated in the Resolution of Necrosis-Associated Sterile Inflammation.

Mona H C Biermann, Malgorzata J Podolska, Jasmin Knopf, Christiane Reinwald, Daniela Weidner, Christian Maueröder, Jonas Hahn, Deborah Kienhöfer, Alexandre Barras, Rabah Boukherroub and 7 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Beyond Killing: The Overlooked Contribution of Neutrophils to Tissue Repair.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Neutrophil extracellular traps and long COVID.Frontiers in immunology · 2023
    Review
  8. Resolution Potential of Necrotic Cell Death Pathways.International journal of molecular sciences · 2022
    Review
  9. Article
  10. Role of the renin-angiotensin system in NETosis in the coronavirus disease 2019 (COVID-19).Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. NETosis as a Pathogenic Factor for Heart Failure.Oxidative medicine and cellular longevity · 2021
    Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 4 countries.

Mona H C BiermannDepartment of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg , Erlangen , Germany.
Malgorzata J PodolskaDepartment of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg , Erlangen , Germany.
Jasmin KnopfDepartment of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg , Erlangen , Germany.
Christiane ReinwaldDepartment of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg , Erlangen , Germany.
Daniela WeidnerDepartment of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg , Erlangen , Germany.
Christian MaueröderDepartment of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg , Erlangen , Germany.
Jonas HahnDepartment of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg , Erlangen , Germany.
Deborah KienhöferDepartment of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg , Erlangen , Germany.
Alexandre BarrasUMR CNRS 8520, Institut d'Electronique de Microélectronique et de Nanotechnologie (IEMN), Université Lille 1 , Villeneuve d'Ascq , France.
Rabah BoukherroubUMR CNRS 8520, Institut d'Electronique de Microélectronique et de Nanotechnologie (IEMN), Université Lille 1 , Villeneuve d'Ascq , France.
Sabine SzuneritsUMR CNRS 8520, Institut d'Electronique de Microélectronique et de Nanotechnologie (IEMN), Université Lille 1 , Villeneuve d'Ascq , France.
Rostyslav BilyyDanylo Halytsky Lviv National Medical University , Lviv , Ukraine.
Markus HoffmannDepartment of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg , Erlangen , Germany.
Yi ZhaoDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University , Chengdu , China.
Georg SchettDepartment of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg , Erlangen , Germany.
Martin HerrmannDepartment of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg , Erlangen , Germany.
Luis E MunozDepartment of Internal Medicine 3 - Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg , Erlangen , Germany.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversitätsklinikum Erlangen · DEInstitut d'électronique de microélectronique et de nanotechnologie · FRCentre National de la Recherche Scientifique · FRDanylo Halytsky Lviv National Medical University · UASichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Necrosis is associated with a profound inflammatory response. The regulation of necrosis-associated inflammation, particularly the mechanisms responsible for resolution of inflammation is incompletely characterized. Nanoparticles are known to induce plasma membrane damage and necrosis followed by sterile inflammation. We observed that injection of metabolically inert nanodiamonds resulted in paw edema in WT and

Indexed as

inflammationnanodiamondsnecrosisNETosisreactive oxygen speciesresolution

Identifiers

PMID27990145
PMCPMC5131011
OpenAlexW2557296231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.