ArticleThe Journal of veterinary medical science2017
Retrospective analysis of canine gallbladder contents in biliary sludge and gallbladder mucoceles.
Article in The Journal of veterinary medical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- Ultrasonographic Gallbladder Findings and Bile Culture Results in Dogs with Extrahepatic Biliary Disorders: A Retrospective Exploratory Case Series.Life (Basel, Switzerland) · 2026Article
- Nutritional Factors Related to Canine Gallbladder Diseases-A Scoping Review.Veterinary sciences · 2024Review
- Characteristics of gallbladder microbiome in healthy dogs and cats, dogs with gallbladder mucocele, and cats with suspected cholangitis/cholangiohepatitis.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2024Article
- MUC5AC and MUC5B expression in canine gallbladder mucocele epithelial cells.The Journal of veterinary medical science · 2023Article
- Canine Gallbladder Erosion/Ulcer and Hemocholecyst: Clinicopathological Characteristics of 14 Cases.Animals : an open access journal from MDPI · 2023Article
- Effects of proportions of carbohydrates and fats in diets on mucin concentration and bile composition in gallbladder of dogs.The Journal of veterinary medical science · 2022Article
- A multicenter retrospective study assessing progression of biliary sludge in dogs using ultrasonography.Journal of veterinary internal medicine · 2022Article
- Factors affecting survival in 516 dogs that underwent cholecystectomy for the treatment of gallbladder mucocele.The Canadian veterinary journal = La revue veterinaire canadienne · 2022Article
- Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver.Animals : an open access journal from MDPI · 2021Article
- Long-term survival of dogs treated for gallbladder mucocele by cholecystectomy, medical management, or both.Journal of veterinary internal medicine · 2019Article
- Comprehensive gene expression analysis in gallbladder mucosal epithelial cells of dogs with gallbladder mucocele.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathophysiology of canine gallbladder diseases, including biliary sludge, gallbladder mucoceles and gallstones, is poorly understood. This study aimed to evaluate the component of gallbladder contents and bacterial infection of the gallbladder in order to elucidate the pathophysiology of biliary sludge and gallbladder mucoceles. A total of 43 samples of canine gallbladder contents (biliary sludge, 21 and gallbladder mucoceles, 22) were subjected to component analysis by infrared spectroscopy, and the resultant infrared spectra were compared with that of swine mucin. Of the 43 samples, 41 were also evaluated by aerobic and anaerobic bacterial culture. The contents of 20 (95.2%) biliary sludge and 22 (100%) gallbladder mucocele samples exhibited similar infrared spectra as swine mucin. Although biliary sludge and gallbladder mucocele contents exhibited similar infrared spectra, one sample of biliary sludge (4.8%) was determined to be composed of proteins. The rate of bacterial infection of the gallbladder was 10.0% for biliary sludge and 14.3% for gallbladder mucoceles. Almost all of the identified bacterial species were intestinal flora. These results indicate that the principal components of gallbladder contents in both gallbladder mucoceles and biliary sludge are mucins and that both pathophysiologies exhibit low rates of bacterial infection of the gallbladder. Therefore, it is possible that gallbladder mucoceles and biliary sludge have the same pathophysiology, and, rather than being independent diseases, they could possibly represent a continuous disease. Thus, biliary sludge could be considered as the stage preceding the appearance of gallbladder mucoceles.
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