Evidence map›Paper›PMID 27989975›Full record

ReviewWorld neurosurgery2017

Is There a Magnetic Resonance Imaging-Discernible Cause for Trigeminal Neuralgia? A Structured Review.

Judy Alper, Raj K Shrivastava, Priti Balchandani

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World neurosurgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. The trigeminal pathways.Journal of neurology · 2022
    Review
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Judy AlperIcahn School of Medicine at Mount Sinai, The Translational and Molecular Imaging Institute, New York, New York, USA; Grove School of Engineering, Department of Biomedical Engineering, City College of New York, New York, New York, USA. Electronic address: judy.alper@mssm.edu.
Raj K ShrivastavaDepartment of Neurosurgery, Mount Sinai Medical Center, New York, New York, USA.
Priti BalchandaniIcahn School of Medicine at Mount Sinai, The Translational and Molecular Imaging Institute, New York, New York, USA.
City College of New York · USIcahn School of Medicine at Mount Sinai · USMount Sinai Medical Center · US

Funding

7T Neurosurgical Mapping Protocol for Endoscopic Resection of Skull Base TumorsR01CA202911 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BALCHANDANI, PRITI · 2016 to 2020
$2.1M
High Resolution Magnetic Resonance Imaging and Spectroscopy of Epilepsy at 7TR00NS070821 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BALCHANDANI, PRITI · 2013 to 2015
$734k
NCI NIH HHS R01 CA202911NINDS NIH HHS R00 NS070821
6 · The paper itself

Abstract

backgroundTrigeminal neuralgia (TN) is a chronic brain condition involving the trigeminal nerve and characterized by severe and recurrent facial pain. Although the cause of TN has been researched extensively, there is a lack of convergence on the physiologic processes leading to pain symptoms. This review seeks to better elucidate the underlying pathophysiology of TN by analyzing the outcomes of studies that use magnetic resonance structural imaging and diffusion-weighted imaging to examine nerve damage in patients with TN.

methodsPerforming a structured review of the literature, the authors included human magnetic resonance anatomic and diffusion-weighted imaging studies aimed at visualizing the trigeminal nerve or measuring neural damage pertaining to TN. Studies that measured and compared nerve damage in the affected and unaffected sides in patients or patients and controls were analyzed for neural changes associated with TN.

resultsTwenty-five studies met inclusion criteria. Overall, the data from the anatomic and diffusion studies showed decreased volume and cross-sectional area, decreased fractional anisotropy, and increased apparent diffusion coefficient and diffusivity associated with the affected side of patients compared with the unaffected side as well as in patients compared with controls.

conclusionsA review of the studies included indicates that neural differences exist between the affected and unaffected sides in patients as well as between patients and controls in both structural and diffusion metrics. The amalgamated data suggest that damage of the trigeminal nerve tissue is commonly found in patients with TN and could be a primary factor in TN pathophysiology.

Indexed as

Magnetic Resonance ImagingAnisotropyDatabases, BibliographicDiffusion Magnetic Resonance ImagingHumansImage Processing, Computer-AssistedTrigeminal NeuralgiaDiffusion-weighted imagingMagnetic resonance imagingNerve damageTrigeminal neuralgia

Identifiers

PMID27989975
PMCPMC5326610
OpenAlexW2541358076

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.