ArticleExperimental gerontology2017
Age differences in dynamic fatigability and variability of arm and leg muscles: Associations with physical function.
Article in Experimental gerontology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Pooled it
- Effects of exercise and whey protein on muscle mass, fat mass, myoelectrical muscle fatigue and health-related quality of life in older adults: a secondary analysis of the Liverpool Hope University-Sarcopenia Ageing Trial (LHU-SAT).European journal of applied physiology · 2020Trial
- Lower-Extremity Torque Capacity and Physical Function in Mobility-Limited Older Adults.The journal of nutrition, health & aging · 2019Trial
- Passive thigh heating increases peak torque but does not attenuate declines in force production during repeated isokinetic knee extensor exercise in older adults.Physiological reports · 2026Article
- Knee extensor muscles of active older adults with knee osteoarthritis are smaller and weaker but not more fatigable than healthy older adults: Relevance to physical function.Osteoarthritis and cartilage open · 2026Article
- Initial contractions of a single-load fatiguing exercise provide a valid assessment of age-related differences in peak power.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Effects of acidosis and inorganic phosphate on CaAmerican journal of physiology. Cell physiology · 2026Article
- Motor performance and aging in males and females.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2025Review
- Mechanisms for the age-related increase in fatigability of the elbow flexor muscles in healthy adults.Physiological reports · 2025Article
- The effect of exercise-induced muscle fatigue on gait parameters among older adults: a systematic review and meta-analysis.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Review
- Are females getting more fatigable as they age?European journal of applied physiology · 2025Article
- Cumulative effects of HThe Journal of physiology · 2025Article
- Association of skeletal muscle oxidative capacity with muscle function, sarcopenia-related exercise performance, and intramuscular adipose tissue in older adults.GeroScience · 2024Article
- Towards a comprehensive biomechanical assessment of the elderly combiningFrontiers in bioengineering and biotechnology · 2024Article
- W Prime: Evidence-Based Proposal for a New Predictor of Gait Speed in Older Women.Muscles (Basel, Switzerland) · 2023Article
- NMES superimposed on movement is equally effective as heavy slow resistance training in patellar tendinopathy.Journal of musculoskeletal & neuronal interactions · 2022Article
- Effects of Physical Activity on Daily Physical Function in Chinese Middle-Aged and Older Adults: A Longitudinal Study from CHARLS.Journal of clinical medicine · 2022Article
- Sex, gender and the pulmonary physiology of exercise.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Interaction between age and fatigue on antagonist muscle coactivation during an acute post-fatigue recovery phase.Frontiers in aging · 2022Article
- Fatigability of the knee extensor muscles during high-load fast and low-load slow resistance exercise in young and older adults.Experimental gerontology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
introductionIt is not known whether the age-related increase in fatigability of fast dynamic contractions in lower limb muscles also occurs in upper limb muscles. We compared age-related fatigability and variability of maximal-effort repeated dynamic contractions in the knee extensor and elbow flexor muscles; and determined associations between fatigability, variability of velocity between contractions and functional performance.
methods35 young (16 males; 21.0±2.6years) and 32 old (18 males; 71.3±6.2years) adults performed a dynamic fatiguing task involving 90 maximal-effort, fast, concentric, isotonic contractions (1 contraction/3s) with a load equivalent to 20% maximal voluntary isometric contraction (MVIC) torque with the elbow flexor and knee extensor muscles on separate days. Old adults also performed tests of balance and walking endurance.
resultsOld adults had greater fatigue-related reductions in peak velocity compared with young adults for both the elbow flexor and knee extensor muscles (P<0.05) with no sex differences (P>0.05). Old adults had greater variability of peak velocity during the knee extensor, but not during the elbow flexor fatiguing task. The age difference in fatigability was greater for the knee extensor muscles (35.9%) compared with elbow flexor muscles (9.7%, P<0.05). Less fatigability of the knee extensor muscles was associated with greater walking endurance (r=-0.34, P=0.048) and balance (r=-0.41, P=0.014) among old adults.
conclusionsAn age-related increase in fatigability of a dynamic fatiguing task was greater for the knee extensor compared with the elbow flexor muscles in males and females, and greater fatigability was associated with lesser walking endurance and balance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.