ArticleCancer cell2017
Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling.
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In one paragraph
Article in Cancer cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 366 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
366citing papers in PubMed, 1 pooled it
19.9field-weighted citation impact, top 1% of its field
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Who cites it
366 citing papers in PubMed, 1 synthesis or guideline pooled it, 521 citations in OpenAlex.
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- Neuron-Associated Transcriptional Enrichment Is Associated with Distinct Biological States and Predicts Poor Prognosis in Gastric Cancer.Annals of surgical oncology · 2026Article
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- Neural regulation of cancer: from synaptic integration to neuro-immune regulation.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Understanding nerve-tumor interactions: From basic biology to therapeutic innovation.Genes & diseases · 2026Review
- The lethal symbiont: exploring the pathophysiology of cancer.Physiological reviews · 2026Review
- Targeting the crosstalk between Alzheimer's disease and gastrointestinal cancers.Molecular medicine (Cambridge, Mass.) · 2026Review
- Neuron-tumor crosstalk in cancer: molecular mechanisms and translational advances.Molecular cancer · 2026Review
- The Potential and Prospects of Marine Drugs in Intervening Nerve-Tumor Crosstalk.Marine drugs · 2026Review
306 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
27 authors at 8 institutions in 6 countries.
Yoku Hayakawa *Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, 10032, USA.
Kosuke Sakitani *Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, 10032, USA.
Mitsuru KonishiDepartment of Gastroenterology, Graduate school of Medicine, the University of Tokyo, Tokyo, 1138655, Japan.
Samuel AsfahaDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, 10032, USA.
Ryota NiikuraDepartment of Gastroenterology, Graduate school of Medicine, the University of Tokyo, Tokyo, 1138655, Japan.
Hiroyuki TomitaDepartment of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, 5011194, Japan.
Bernhard W RenzDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, 10032, USA.
Yagnesh TailorDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, 10032, USA.
Marina MacchiniDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, 10032, USA.
Moritz MiddelhoffDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, 10032, USA.
Zhengyu JiangDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, 10032, USA.
Takayuki TanakaDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, 10032, USA.
Zinaida A DubeykovskayaDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, 10032, USA.
Woosook KimDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, 10032, USA.
Xiaowei ChenDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, 10032, USA.
Aleksandra M UrbanskaDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, 10032, USA.
Karan NagarDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, 10032, USA.
Christoph B WestphalenDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, 10032, USA.
Michael QuanteDepartment of Internal Medicine II, Klinikum rechts der Isar, II. Technische Universität München, Munich, 81675, Germany.
Chyuan-Sheng LinDepartment of Pathology and Cell Biology, Columbia University, New York, NY, 10032, USA.
Michael D GershonDepartment of Pathology and Cell Biology, Columbia University, New York, NY, 10032, USA.
Akira HaraDepartment of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, 5011194, Japan.
Chun-Mei ZhaoDepartment of Cancer Research and Molecular Medicine, NTNU - Norwegian University of Science and Technology, Trondheim, 7491, Norway.
Duan ChenDepartment of Cancer Research and Molecular Medicine, NTNU - Norwegian University of Science and Technology, Trondheim, 7491, Norway.
Daniel L WorthleyDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, 10032, USA.
Kazuhiko KoikeDepartment of Gastroenterology, Graduate school of Medicine, the University of Tokyo, Tokyo, 1138655, Japan.
Timothy C WangDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, 10032, USA.
Columbia University Irving Medical Center · USUniversity of Tokyo Hospital · JPGifu University · JPNorwegian University of Science and Technology · NOColumbia University · USTransgenomic (United States) · USTUM Klinikum · DEWestern University · CA
Funding
The Role of Stem Cells and the Microenvironment in Gastrointestinal CancersR35CA210088 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Timothy Cragin Wang · 2017 to 2026
$10.2MIntestinal Stem Cell Consortium Coordinating CenterU01DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2009 to 2018
$6.5MThe Role of Inflammation and Stroma in Digestive CancerU54CA126513 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WANG, TIMOTHY CRAGIN · 2006 to 2010
$5.1MUnderstanding stem cell heterogeneity and niche function in intestinal regeneration after irradiationU01DK103155 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GUHA, CHANDAN, WANG, TIMOTHY CRAGIN · 2014 to 2023
$4.4MRole of Inflamation in Mouse Models of Gastric CancerR01CA093405 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WANG, TIMOTHY CRAGIN · 2001 to 2016
$3.8MLimited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating CenterU24DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2019 to 2023
$2.3MStem Cells and Gastric CancerR01CA120979 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WANG, TIMOTHY CRAGIN · 2006 to 2010
$2.3MFUNCTION AND REGULATION OF GASTRINR01DK052778 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WANG, TIMOTHY CRAGIN · 1997 to 2008
$1.8MQuiescent Dclk1+ stem cells in the mouse intestineR01DK097016 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WANG, TIMOTHY CRAGIN · 2013 to 2015
$950kNCI NIH HHS R01 CA093405NCI NIH HHS R01 CA120979NCI NIH HHS R35 CA210088NCI NIH HHS U54 CA126513NIDDK NIH HHS R01 DK052778NIDDK NIH HHS R01 DK097016NIDDK NIH HHS U01 DK085532NIDDK NIH HHS U01 DK103155NIDDK NIH HHS U24 DK085532
Abstract
Within the gastrointestinal stem cell niche, nerves help to regulate both normal and neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying the cancer-nerve partnership. We find that Dclk1
Indexed as
AcetylcholineAdaptor Proteins, Signal TransducingAnimalsCell Cycle ProteinsDoublecortin-Like KinasesGastric MucosaMiceMice, Inbred C57BLNerve Growth FactorPhosphoproteinsProtein Serine-Threonine KinasesReceptor, Muscarinic M3Signal TransductionStomach NeoplasmsYAP-Signaling ProteinsAcetylcholineAdaptor Proteins, Signal TransducingCell Cycle ProteinsDclk1 protein, mouseDoublecortin-Like KinasesNerve Growth FactorPhosphoproteinsProtein Serine-Threonine KinasesReceptor, Muscarinic M3Yap1 protein, mouseYAP-Signaling ProteinsacetylcholineDclk1gastric cancerLgr5muscarinic acetylcholine receptor type 3NGFstem celltuft cellwntYAP
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.