ArticleCell stem cell2017
Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation.
Open access · bronzeAbstract read
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Article in Cell stem cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers.
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140citing papers in PubMed
14.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
140 citing papers in PubMed, 265 citations in OpenAlex.
- Generation of human primordial germ cell-like cells from cumulus and blood cell-derived isogenic human induced pluripotent stem cells†.Biology of reproduction · 2026Article
- Chromosome X dosage modulates development of aneuploidy in genetically diverse mouse embryonic stem cells.Stem cell reports · 2026Article
- Article
- Establishment and Maintenance of Repressed Chromatin States on Dosage-Compensated Sex Chromosomes.Biomolecules · 2026Review
- Amniogenesis in embryos and stem cell models.Nature cell biology · 2026Review
- Exiting the ground state: the broad spectrum of cell fates accessible from naïve human pluripotent stem cells.Cellular and molecular life sciences : CMLS · 2026Review
- Lyonization of X-chromosome: New insights.Journal of genetics · 2026Review
- H3K27ac Is Essential for Human Naive Pluripotency Modulated by m6A-Driven EP300 Expression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- BACH1 recruits STAT3 to enhance leukemia inhibitory factor receptor activity and augments the self-renewal capacity of mouse embryonic stem cells.Stem cell research & therapy · 2025Article
- Addressing Sex as a Biological Variable in Preclinical Models of Lung Disease: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2025Article
- X chromosome inactivation in mammals: general principles and species-specific considerations.EMBO reports · 2025Review
- Proteogenomic reprogramming to a functional human blastomere-like stem cell state via a PARP-DUX4 regulatory axis.Cell reports · 2025Article
- Human XIST: Origin and Divergence of aNon-coding RNA · 2025Review
- The guinea pig serves as an alternative model to study human preimplantation development.Nature cell biology · 2025Article
- Tracking and mitigating imprint erasure during induction of naive human pluripotency at single-cell resolution.Stem cell reports · 2025Article
- Chromatin landscape dynamics during reprogramming towards human naïve and primed pluripotency reveals the divergent function of PRDM1 isoforms.Cell death discovery · 2024Article
- ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency.Nature communications · 2024Article
- XIST dampens X chromosome activity in a SPEN-dependent manner during early human development.Nature structural & molecular biology · 2024Article
- Modeling X chromosome inactivation using t5iLA naive human pluripotent stem cells.BMC biology · 2024Article
- Using Organoids to Model Sex Differences in the Human Brain.Biological psychiatry global open science · 2024Review
80 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 3 institutions in 1 country.
Anna SahakyanDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Rachel KimEli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Constantinos ChronisDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Shan SabriDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Giancarlo BonoraDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA; Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Thorold W TheunissenWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Edward KuoyDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Justin LangermanDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Amander T ClarkMolecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Rudolf JaenischWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Kathrin PlathDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: kplath@mednet.ucla.edu.
University of California, Los Angeles · USBroad Center · USWhitehead Institute for Biomedical Research · US
Funding
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MRoles of sumoylation and alternative polyadenylation in cellular reprogrammingP01GM099134 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOCHEDLINGER, KONRAD · 2011 to 2021
$20.3MIn Vitro Reprogramming of Somatic Cells into Pluripotent ES-like CellsR37HD045022 · NICHD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI JAENISCH, RUDOLF · 2009 to 2017
$7.5MTranscriptional condensates, epigenetic editing and Rett SyndromeR01MH104610 · NIMH · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI JAENISCH, RUDOLF, YOUNG, RICHARD · 2014 to 2023
$7.4MAn iPSC based platform for functionally assessing genetic and environmental riskR01NS088538 · NINDS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI JAENISCH, RUDOLF, MYERS, RICHARD H · 2014 to 2018
$5.0MNuclear Cloning and the Reprogramming of the GenomeR01HD045022 · NICHD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI JAENISCH, RUDOLF · 2003 to 2008
$4.7MProgramming and Reprogramming Human CellsR01CA084198 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI JAENISCH, RUDOLF · 2009 to 2013
$4.3MDifferentiating embryonic stem cells into developing germ lineR01HD079546 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CLARK, AMANDER · 2015 to 2024
$3.7MMechanisms of XIST RNA-induced gene silencing in humansF31GM115122 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAHAKYAN, ANNA · 2015 to 2016
$70kNCATS NIH HHS UL1 TR000124NCI NIH HHS R01 CA084198NICHD NIH HHS R01 HD045022NICHD NIH HHS R01 HD079546NICHD NIH HHS R37 HD045022NIGMS NIH HHS F31 GM115122NIGMS NIH HHS P01 GM099134NIMH NIH HHS R01 MH104610NINDS NIH HHS R01 NS088538Wellcome TrustWellcome Trust 098889/Z/12/Z
Abstract
Naive human embryonic stem cells (hESCs) can be derived from primed hESCs or directly from blastocysts, but their X chromosome state has remained unresolved. Here, we show that the inactive X chromosome (X
Indexed as
Base SequenceBlastocystCell DifferentiationCells, CulturedChromosomes, Human, XDNA MethylationFemaleHistonesHuman Embryonic Stem CellsHumansLysineMethylationPluripotent Stem CellsRNA, Long NoncodingX Chromosome InactivationHistonesLysineRNA, Long NoncodingXIST non-coding RNAembryonic stem cellshuman developmenthuman stem cellslncRNAnaive pluripotencypluripotent stem cellsX chromosomeX chromosome dampeningX chromosome inactivationXIST
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