Evidence map›Paper›PMID 27989753›Full record

ArticleFree radical biology & medicine2016

The tetrahydrobiopterin radical interacting with high- and low-spin heme in neuronal nitric oxide synthase - A new indicator of the extent of NOS coupling.

Matthew D Krzyaniak, Alex A Cruce, Preethi Vennam, Molly Lockart, Vladimir Berka, Ah-Lim Tsai, Michael K Bowman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Matthew D KrzyaniakDepartment of Chemistry, The University of Alabama, Tuscaloosa, AL 35487-0336, USA.
Alex A CruceDepartment of Chemistry, The University of Alabama, Tuscaloosa, AL 35487-0336, USA.
Preethi VennamDepartment of Chemistry, The University of Alabama, Tuscaloosa, AL 35487-0336, USA.
Molly LockartDepartment of Chemistry, The University of Alabama, Tuscaloosa, AL 35487-0336, USA.
Vladimir BerkaDivision of Hematology, Department of Internal Medicine, University of Texas Health Science Center, Houston, TX 77030, USA.
Ah-Lim TsaiDivision of Hematology, Department of Internal Medicine, University of Texas Health Science Center, Houston, TX 77030, USA.
Michael K BowmanDepartment of Chemistry, The University of Alabama, Tuscaloosa, AL 35487-0336, USA. Electronic address: mkbowman@ua.edu.
University of Alabama · USThe University of Texas Health Science Center at Houston · US

Funding

Radical Intermediates of Nitric Oxide Synthase & Myocardial Ischemia ReperfusionR01HL095820 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TSAI, AH-LIM · 2010 to 2013
$1.8M
NHLBI NIH HHS R01 HL095820
6 · The paper itself

Abstract

Reaction intermediates trapped during the single-turnover reaction of the neuronal ferrous nitric oxide synthase oxygenase domain (Fe(II)nNOS

Indexed as

AnimalsBiopterinsBrain ChemistryElectron Spin Resonance SpectroscopyFree RadicalsGene ExpressionHemeNitric Oxide Synthase Type IOxidation-ReductionProtein DomainsRatsRecombinant ProteinsSolutionsTemperatureBiopterinsFree RadicalsHemeNitric Oxide Synthase Type INos1 protein, ratRecombinant ProteinssapropterinSolutionsENDOREPRESEEMNitric oxide synthaseTetrahydrobiopterin radical

Identifiers

PMID27989753
PMCPMC5362310
OpenAlexW2539991325

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.