ArticleCell reports2017
Human Embryonic Stem Cells Do Not Change Their X Inactivation Status during Differentiation.
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Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
9.4field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 124 citations in OpenAlex.
- Reversible epiblast regionalization determines differentiation potential of human pluripotent stem cells.Nature biotechnology · 2026Article
- Neural peer pressure: intercellular dynamics and emergent phenotypes in the mosaic Rett syndrome brain.Cell communication and signaling : CCS · 2026Review
- Highly efficient XIST reactivation in female hPSC by transient dual inhibition of TP53 and DNA methylation during Cas9 mediated genome editing.Stem cell research & therapy · 2025Article
- Gene reactivation upon erosion of X chromosome inactivation in female hiPSCs is predictable yet variable and persists through differentiation.Stem cell reports · 2025Article
- Human XIST: Origin and Divergence of aNon-coding RNA · 2025Review
- X-Linked Gene Dosage and SOX2 Act as Key Roadblocks for Human Germ Cell Specification in Klinefelter Syndrome.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Defective X-chromosome inactivation and cancer risk in women.Communications biology · 2025Article
- Modeling X chromosome inactivation using t5iLA naive human pluripotent stem cells.BMC biology · 2024Article
- Using Organoids to Model Sex Differences in the Human Brain.Biological psychiatry global open science · 2024Review
- X-chromosome inactivation in human iPSCs provides insight into X-regulated gene expression in autosomes.Genome biology · 2024Article
- Article
- EpiTyping: analysis of epigenetic aberrations in parental imprinting and X-chromosome inactivation using RNA-seq.Nature protocols · 2023Review
- IndiSPENsable for X Chromosome Inactivation and Gene Silencing.Epigenomes · 2023Review
- Modeling X-chromosome inactivation and reactivation during human development.Current opinion in genetics & development · 2023Review
- Female naïve human pluripotent stem cells carry X chromosomes with Xa-like and Xi-like folding conformations.Science advances · 2023Article
- Induction of fetal meiotic oocytes from embryonic stem cells in cynomolgus monkeys.The EMBO journal · 2023Article
- Characterisation of X chromosome status of human extended pluripotent stem cells.Cell proliferation · 2023Article
- De-erosion of X chromosome dosage compensation by the editing ofCell reports methods · 2022Article
- A lifelong duty: how Xist maintains the inactive X chromosome.Current opinion in genetics & development · 2022Review
- Large-Scale Analysis of X Inactivation Variations between Primed and Naïve Human Embryonic Stem Cells.Cells · 2022Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 1 country.
Sanjeet PatelDepartment of Biological Chemistry, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Bioinformatics Program, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Giancarlo BonoraDepartment of Biological Chemistry, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Bioinformatics Program, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Anna SahakyanDepartment of Biological Chemistry, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Bioinformatics Program, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Rachel KimDepartment of Biological Chemistry, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Bioinformatics Program, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Constantinos ChronisDepartment of Biological Chemistry, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Bioinformatics Program, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Justin LangermanDepartment of Biological Chemistry, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Bioinformatics Program, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Sorel Fitz-GibbonDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Liudmilla RubbiDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Rhys J P SkeltonDivision of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Reza ArdehaliDivision of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Matteo PellegriniDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
William E LowryDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Amander T ClarkDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Kathrin PlathDepartment of Biological Chemistry, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Bioinformatics Program, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: kplath@mednet.ucla.edu.
University of California, Los Angeles · USBroad Center · US
Funding
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MRoles of sumoylation and alternative polyadenylation in cellular reprogrammingP01GM099134 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOCHEDLINGER, KONRAD · 2011 to 2021
$20.3MDifferentiating embryonic stem cells into developing germ lineR01HD079546 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CLARK, AMANDER · 2015 to 2024
$3.7MMechanisms of XIST RNA-induced gene silencing in humansF31GM115122 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAHAKYAN, ANNA · 2015 to 2016
$70kNCATS NIH HHS UL1 TR000124NICHD NIH HHS R01 HD079546NIGMS NIH HHS F31 GM115122NIGMS NIH HHS P01 GM099134
Abstract
Applications of embryonic stem cells (ESCs) require faithful chromatin changes during differentiation, but the fate of the X chromosome state in differentiating ESCs is unclear. Female human ESC lines either carry two active X chromosomes (XaXa), an Xa and inactive X chromosome with or without XIST RNA coating (Xi
Indexed as
Cell DifferentiationCell LineDNA MethylationFemaleGene Expression RegulationGene SilencingHuman Embryonic Stem CellsHumansInduced Pluripotent Stem CellsIn Situ Hybridization, FluorescenceMaleSequence Analysis, RNATretinoinX Chromosome InactivationTretinoinDNA methylationhuman embryonic stem cellshuman induced pluripotent stem cellsinactive X chromosomeX-chromosome dosage compensationXi-erosionX-inactivationXist
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